{"id":"W3161110562","doi":"10.1101/2021.05.12.443794","title":"A sex-specific evolutionary interaction between <i>ADCY9</i> and <i>CETP</i>","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Canadian Institutes of Health Research; Institut de Cardiologie de Montréal; Fonds de Recherche du Québec - Santé; Institut de Valorisation des Données; Compute Canada","keywords":"Cholesterylester transfer protein; Biology; Genetics; Single-nucleotide polymorphism; Population; Linkage disequilibrium; Locus (genetics); Epistasis; Gene; Genotype; Medicine; Cholesterol; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003233828,0.0002164604,0.0002053348,0.0002625425,0.0003160844,0.0003676849,0.0002254095,0.0003763837,0.008307667],"category_scores_gemma":[0.0006610586,0.0001222825,0.0003705008,0.0003241582,0.0002525209,0.0001119307,0.0003323044,0.0005403014,0.0006054678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001231055,"about_ca_system_score_gemma":0.0001239965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001812713,"about_ca_topic_score_gemma":0.002350528,"domain_scores_codex":[0.9997494,0.0000545859,0.00001280677,0.0001135543,0.00003339167,0.00003641949],"domain_scores_gemma":[0.9997028,0.00008502865,0.0001206437,0.00003591489,0.00001913022,0.00003646353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002769326,0.00008797115,0.5555102,0.0002305221,0.001114785,0.003207898,0.0005132426,0.0005110595,0.3899592,0.001505735,0.00330525,0.04128485],"study_design_scores_gemma":[0.00007587068,0.0002707512,0.9794419,0.00002716053,0.00019675,0.002636653,0.0001263657,0.0006703963,0.009337652,0.0005758893,0.006619642,0.0000210342],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914425,0.001104397,0.002021866,0.000742305,0.00005031136,0.00001422704,0.00174606,0.00008556267,0.00279284],"genre_scores_gemma":[0.9958145,0.0002538634,0.0006713541,0.0004254024,0.0000465398,0.00001296411,0.0008343021,0.00004054321,0.001900573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008307667,"threshold_uncertainty_score":0.02779192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01965788958246332,"score_gpt":0.2362300816796835,"score_spread":0.2165721920972202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}