{"id":"W3161134143","doi":"10.1021/acscentsci.1c00520","title":"Glycosylated Polyene Macrolides Kill Fungi via a Conserved Sterol Sponge Mechanism of Action","year":2021,"lang":"en","type":"article","venue":"ACS Central Science","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Animal Health and Welfare ERA-Net; Canada Research Chairs; Canadian Institute for Advanced Research","keywords":"License; Polyene; World Wide Web; Library science; Chemistry; Computational biology; Computer science; Biology; Political science; Law; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002360971,0.0008317659,0.0002780779,0.0005028929,0.000352065,0.0008687828,0.0002965064,0.0004599224,0.05136859],"category_scores_gemma":[0.0002264275,0.0002541072,0.0004192385,0.0003140949,0.0003419723,0.0005601627,0.000569852,0.0009180099,0.02434156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000505313,"about_ca_system_score_gemma":0.0004776977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007784902,"about_ca_topic_score_gemma":0.001507559,"domain_scores_codex":[0.9997186,0.0000199908,0.00001385165,0.00003050894,0.0001430837,0.00007394626],"domain_scores_gemma":[0.9998279,0.00001230105,0.00003519918,0.00002334452,0.00005320395,0.0000481879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003673685,0.0000995189,0.0006428816,0.000349397,0.00001940466,0.0001997537,0.00005103927,0.0001468302,0.9272663,0.004216044,0.01437667,0.05226477],"study_design_scores_gemma":[0.00006149466,0.0006829242,0.004795219,0.00007602142,0.00002651307,0.0004712539,0.00009333839,0.0005174605,0.8335287,0.001061137,0.1586628,0.00002313376],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.3636757,0.03355775,0.04982323,0.007688524,0.004939083,0.001260906,0.01388498,0.004887051,0.5202827],"genre_scores_gemma":[0.5907069,0.02110785,0.01915754,0.001542182,0.0003468933,0.000278819,0.006747203,0.0006147767,0.359498],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.05136859,"threshold_uncertainty_score":0.1718451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02686538641491195,"score_gpt":0.2950937652330741,"score_spread":0.2682283788181622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}