{"id":"W3161134143","doi":"10.1021/acscentsci.1c00520","title":"Glycosylated Polyene Macrolides Kill Fungi via a Conserved Sterol Sponge Mechanism of Action","year":2021,"lang":"en","type":"article","venue":"ACS Central Science","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Animal Health and Welfare ERA-Net; Canada Research Chairs; Canadian Institute for Advanced Research","keywords":"License; Polyene; World Wide Web; Library science; Chemistry; Computational biology; Computer science; Biology; Political science; Law; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00038465,0.000117784,0.0002498353,0.00005860346,0.0001301548,0.00002666222,0.0001551334,0.00007002117,0.0003283424],"category_scores_gemma":[0.0002789052,0.00009986924,0.0000805251,0.0007355188,0.0003415401,0.0002430203,0.00006985138,0.0001337222,0.00001765356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000138977,"about_ca_system_score_gemma":0.0004995269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001504676,"about_ca_topic_score_gemma":0.0002394398,"domain_scores_codex":[0.9982991,0.00004496728,0.0002692628,0.0003986002,0.0004831702,0.0005049059],"domain_scores_gemma":[0.9989189,0.00004689794,0.00009459131,0.0003757163,0.0003190232,0.000244887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002400505,0.0001230341,0.03696256,0.00005435349,0.00001312009,0.00006052529,0.0001422637,0.000001125558,0.9560145,0.0006445159,0.0000244949,0.005719518],"study_design_scores_gemma":[0.0004468746,0.0001058705,0.2988163,0.00005876979,0.00003084712,0.000045092,0.0001738097,0.0003794539,0.6994276,0.0003290728,0.0001099231,0.00007643538],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971573,0.0002530265,0.001054483,0.0004217358,0.0002752936,0.0001937345,0.00001213055,0.00003787918,0.0005944517],"genre_scores_gemma":[0.9983795,0.0001437476,0.0004529999,0.0003468077,0.00003529057,0.000002128857,0.000008633029,0.000007097481,0.0006238008],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2618537,"threshold_uncertainty_score":0.407255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02686538641491195,"score_gpt":0.2950937652330741,"score_spread":0.2682283788181622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}