{"id":"W3161156709","doi":"10.1038/s41467-021-23124-w","title":"Total genetic contribution assessment across the human genome","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Global Health Research","funders":"Vetenskapsrådet; University of Edinburgh","keywords":"Locus (genetics); Phenome; Biology; Biobank; Genome-wide association study; Genetics; Gene; Quantitative trait locus; Genome; Genetic variation; Genetic association; Computational biology; Evolutionary biology; Genotype; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004657713,0.0007023729,0.0009185011,0.002433265,0.0003906,0.001635221,0.0007778258,0.000640303,0.0030231],"category_scores_gemma":[0.011544,0.0003644784,0.001448294,0.002605473,0.000627269,0.0007512834,0.001986466,0.0008330882,0.0004267209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003822877,"about_ca_system_score_gemma":0.0007696413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00442545,"about_ca_topic_score_gemma":0.003918209,"domain_scores_codex":[0.9982162,0.0007220937,0.00007952189,0.0006099212,0.000309029,0.00006321901],"domain_scores_gemma":[0.9963742,0.002221271,0.000256048,0.0008168626,0.0002475952,0.00008392679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0006086407,0.00007829592,0.2289105,0.0006954932,0.004370802,0.0009575161,0.001230268,0.2914177,0.04741102,0.06593072,0.006573844,0.3518153],"study_design_scores_gemma":[0.00008074628,0.0003295961,0.1912156,0.0002037087,0.001291452,0.00217069,0.0003425674,0.5445424,0.008587573,0.2246138,0.02645985,0.0001621646],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1556191,0.001332351,0.8314916,0.0005685565,0.00007796069,0.00009430762,0.003723302,0.00220047,0.004892386],"genre_scores_gemma":[0.7732874,0.001047762,0.2192596,0.0003329906,0.00006973281,0.0003111667,0.002680108,0.0004503936,0.002560834],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004657713,"threshold_uncertainty_score":0.02463263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01480048337552796,"score_gpt":0.3570405325350636,"score_spread":0.3422400491595357,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}