{"id":"W3161220247","doi":"10.1021/acs.molpharmaceut.1c00208","title":"Incorporation of a Novel CD16-Specific Single-Domain Antibody into Multispecific Natural Killer Cell Engagers With Potent ADCC","year":2021,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; National Research Council Canada","funders":"National Research Council Canada","keywords":"CD16; Antibody-dependent cell-mediated cytotoxicity; Single-domain antibody; Antibody; Antigen; Degranulation; Biology; Molecular biology; Immunology; Immunotherapy; Effector; Chemistry; Immune system; Monoclonal antibody; Receptor; CD3; Biochemistry; CD8","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002065548,0.0003498983,0.0002728327,0.0001459623,0.00008154241,0.0003218385,0.0003029728,0.0003492549,0.0006763461],"category_scores_gemma":[0.0001806656,0.0001165598,0.0002438182,0.00008797269,0.0001566293,0.000271098,0.0002871184,0.0005522286,0.0002875041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003549175,"about_ca_system_score_gemma":0.0002000022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002569371,"about_ca_topic_score_gemma":0.0006716301,"domain_scores_codex":[0.999855,0.00001969214,0.00001474844,0.00003190557,0.00004026324,0.00003829253],"domain_scores_gemma":[0.9998993,0.00001417658,0.0000298971,0.00001593671,0.00001672566,0.00002402643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004528558,0.00005010626,0.000196075,0.00003083803,0.000006483375,0.00003605385,0.000009193913,0.0001667021,0.9955683,0.0001073733,0.00003001083,0.003753491],"study_design_scores_gemma":[0.00004224835,0.0005560318,0.0005890136,0.000004941846,0.00001676063,0.0003663113,0.000006462999,0.001297991,0.993538,0.00002911106,0.003548814,0.0000042965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9777444,0.002549767,0.01751477,0.000139479,0.00003974826,0.0001465035,0.0001084292,0.000132618,0.001624339],"genre_scores_gemma":[0.9839877,0.0006512154,0.01297472,0.00007360362,0.00001382598,0.00005780108,0.000231239,0.00001222413,0.001997715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006763461,"threshold_uncertainty_score":0.002575099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04321509981330846,"score_gpt":0.3365767834033317,"score_spread":0.2933616835900233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}