{"id":"W3161231300","doi":"10.1016/j.jgar.2021.03.025","title":"Real-life experience with ceftolozane/tazobactam in Canada: results from the CLEAR (Canadian LEadership on Antimicrobial Real-life usage) registry","year":2021,"lang":"en","type":"article","venue":"Journal of Global Antimicrobial Resistance","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Boniface Hospital; Moncton Hospital; University of Manitoba; Centre intégré universitaire de santé et de services sociaux de l'Est-de-l'Île-de-Montréal; Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Hamilton Health Sciences; Ottawa Hospital; Health Sciences Centre; William Osler Health System; University of Alberta; Royal University Hospital; London Health Sciences Centre","funders":"Merck Canada; Basilea Pharmaceutica; Meso Scale Diagnostics; Angelini Pharma; Astellas Pharma Canada; Gilead Sciences; Roche; Shionogi; Merck; University of Manitoba; Bayer; Pfizer","keywords":"Medicine; Tazobactam; Colistin; Pneumonia; Antimicrobial; Intensive care medicine; Internal medicine; Antibiotics; Antibiotic resistance; Microbiology; Biology; Imipenem","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000387096,0.0004098312,0.0005864079,0.00003745217,0.0002270692,0.0001588341,0.000965644,0.0002673308,0.00002622205],"category_scores_gemma":[0.001055775,0.0003257391,0.0001676077,0.0004645962,0.00034713,0.00003259759,0.00009126394,0.0004742717,0.000005975632],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009726301,"about_ca_system_score_gemma":0.0120114,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.6290976,"about_ca_topic_score_gemma":0.9885507,"domain_scores_codex":[0.9965666,0.0003258159,0.001081781,0.0007029718,0.0005064368,0.0008164165],"domain_scores_gemma":[0.9971831,0.0001090374,0.0008678416,0.0009076433,0.0004175367,0.0005147803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.02558221,0.0003101795,0.2290497,0.0001299667,0.000454187,0.004523378,0.000383932,0.0008180266,0.437448,0.0004923615,0.3006491,0.0001589475],"study_design_scores_gemma":[0.004441021,0.0002883268,0.8953573,0.001844624,0.00008497659,0.0003186975,0.002777687,0.000007180112,0.06326354,0.00001564025,0.03061317,0.0009878312],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878032,0.0002852906,0.00003434703,0.007484735,0.0005964229,0.0001610946,0.0007816121,0.000005940687,0.002847386],"genre_scores_gemma":[0.992887,0.001491199,0.0007815419,0.003748903,0.0005399825,9.015703e-7,0.0000869706,0.0000366155,0.0004268671],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6663076,"threshold_uncertainty_score":0.9999195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0185328351067521,"score_gpt":0.2348561267657132,"score_spread":0.2163232916589611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}