{"id":"W3161237071","doi":"10.2139/ssrn.3839396","title":"Preclinical Assessment of a Gene Editing Approach in a Mouse Model of MNGIE","year":2021,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"","keywords":"Genome editing; Computational biology; Gene; Biology; Preclinical testing; Computer science; Genetics; Psychology; CRISPR; Bioinformatics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001211452,0.001813208,0.001035248,0.001258799,0.000669021,0.001046806,0.001330455,0.002351701,0.004232462],"category_scores_gemma":[0.0005252158,0.0003764781,0.001003302,0.0003549657,0.001265301,0.001081479,0.0003353095,0.003972762,0.001198107],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008492586,"about_ca_system_score_gemma":0.0009435778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001044432,"about_ca_topic_score_gemma":0.002337697,"domain_scores_codex":[0.9994948,0.00009576618,0.00004342797,0.0001430446,0.00009921374,0.0001237497],"domain_scores_gemma":[0.9992372,0.0001118017,0.0001765501,0.00009972682,0.0001141029,0.0002606791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01002676,0.01257523,0.0004718991,0.0003460273,0.0001508866,0.0005645548,0.0001425983,0.001240185,0.9599162,0.001916616,0.001368791,0.01128017],"study_design_scores_gemma":[0.004373449,0.1205369,0.002425678,0.0002071093,0.0005342045,0.001032753,0.0002346713,0.003733018,0.8506302,0.0009324271,0.01529128,0.00006831458],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9705454,0.002402043,0.01362978,0.001569972,0.0007943149,0.001919336,0.002707098,0.0009149155,0.005517191],"genre_scores_gemma":[0.9624598,0.002936308,0.0091199,0.0006371697,0.0001416745,0.00237256,0.002825522,0.0001178954,0.0193892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004232462,"threshold_uncertainty_score":0.01415902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02469732559653484,"score_gpt":0.3053938993487977,"score_spread":0.2806965737522629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}