{"id":"W3161239394","doi":"10.1128/msphere.00185-21","title":"Primed CRISPR-Cas Adaptation and Impaired Phage Adsorption in Streptococcus mutans","year":2021,"lang":"en","type":"article","venue":"mSphere","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Government of Canada","keywords":"CRISPR; Bacteriophage; Biology; Virulence; Microbiology; Plasmid; Phagemid; Genome; Virology; Genetics; Gene; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001267902,0.0002956173,0.000267774,0.0002431074,0.0001412914,0.0002381175,0.0002535552,0.0004740657,0.001180619],"category_scores_gemma":[0.0002695968,0.0001510324,0.000291915,0.0001571853,0.0002684099,0.0001119311,0.0002823965,0.0005229503,0.0003027926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000294315,"about_ca_system_score_gemma":0.0003320267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002046254,"about_ca_topic_score_gemma":0.001145506,"domain_scores_codex":[0.9997537,0.00004499787,0.00003302728,0.00003822206,0.00009052017,0.00003955778],"domain_scores_gemma":[0.9998642,0.00002653908,0.00005202237,0.0000155321,0.000008683602,0.00003303102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001442159,0.00007299068,0.0006609978,0.00002828751,0.000009522044,0.0003470122,0.00001817038,0.000250089,0.9964911,0.0002141795,0.00006683835,0.001696519],"study_design_scores_gemma":[0.00002520486,0.0003512701,0.03767009,0.00001197727,0.00002803355,0.002090452,0.00007366737,0.005226184,0.9528723,0.0003649487,0.001259208,0.00002666621],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978291,0.0002522932,0.001079135,0.00007938727,0.0000205464,0.000008174837,0.0001562674,0.00007352114,0.0005014663],"genre_scores_gemma":[0.9983369,0.00008666638,0.0003717949,0.00002913799,0.000002569074,0.000005982924,0.0001002359,0.00001205963,0.001054615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002046254,"threshold_uncertainty_score":0.004068613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01041386739591643,"score_gpt":0.2807219920823678,"score_spread":0.2703081246864514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}