{"id":"W3161239394","doi":"10.1128/msphere.00185-21","title":"Primed CRISPR-Cas Adaptation and Impaired Phage Adsorption in Streptococcus mutans","year":2021,"lang":"en","type":"article","venue":"mSphere","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Government of Canada","keywords":"CRISPR; Bacteriophage; Biology; Virulence; Microbiology; Plasmid; Phagemid; Genome; Virology; Genetics; Gene; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005217217,0.00008821733,0.00007986497,0.00001229493,0.00001540365,0.00001726745,0.00003528623,0.00008661439,0.00005943116],"category_scores_gemma":[0.00004410677,0.0000967621,0.00002575877,0.00008604353,0.0000136712,0.000002966603,0.00003642524,0.00005255815,0.000003724892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001106521,"about_ca_system_score_gemma":0.0000428578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002535571,"about_ca_topic_score_gemma":0.0006517738,"domain_scores_codex":[0.9994469,0.00002497416,0.0001179952,0.0002203462,0.00005590377,0.0001338939],"domain_scores_gemma":[0.99974,0.000005385059,0.00002011032,0.0001507335,0.00004048922,0.00004324927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001752446,0.00003388696,0.006660475,0.00002793356,0.00001445754,0.00001665443,0.0002337193,0.001394906,0.9752648,0.00001709081,0.000240567,0.01607802],"study_design_scores_gemma":[0.0008528584,0.00009203628,0.06313839,0.0000237894,0.00001296276,0.00002174009,0.0008679848,0.003154412,0.9270379,0.0000476787,0.004561463,0.0001888236],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817776,0.002277014,0.01516187,0.00006261593,0.00007280032,0.0001165897,0.000006877565,0.00001216147,0.0005124559],"genre_scores_gemma":[0.9981192,0.0001711161,0.001067885,0.00004389678,0.0000713035,0.00001841915,0.00008551549,0.00001311871,0.0004095093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05647791,"threshold_uncertainty_score":0.3945844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01041386739591643,"score_gpt":0.2807219920823678,"score_spread":0.2703081246864514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}