{"id":"W3161270521","doi":"10.1101/2021.05.17.444454","title":"Decoding Angiotensin II Type 1 Receptor Allosteric Communication to Gq and β-arrestin","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Allosteric regulation; G protein-coupled receptor; Arrestin; Chemistry; Binding site; Receptor; G protein; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001071378,0.0001895035,0.0001958365,0.000071968,0.0001584932,0.0002211957,0.0001961073,0.0001449688,0.00118037],"category_scores_gemma":[0.0003129095,0.00008327093,0.0001678764,0.00007340365,0.0001771083,0.000231895,0.0001962502,0.0004409239,0.0002483463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002863158,"about_ca_system_score_gemma":0.0002256632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004837852,"about_ca_topic_score_gemma":0.0007289307,"domain_scores_codex":[0.9999502,0.000008288244,0.000003107584,0.00001336522,0.00001516053,0.000009953797],"domain_scores_gemma":[0.9999374,0.00001959632,0.0000187136,0.000006227974,0.000008533701,0.0000095045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001052332,0.00003200281,0.0009616195,0.00006641002,0.0000138117,0.00009199873,0.00002854653,0.01113146,0.9807618,0.002183307,0.0001624793,0.004461255],"study_design_scores_gemma":[0.00003515089,0.0002469138,0.002837137,0.00001563478,0.00002809,0.0001263349,0.00007046755,0.171815,0.8208738,0.001389829,0.00253727,0.00002428656],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799976,0.0002304641,0.01790288,0.0001461479,0.00003829203,0.00002384482,0.0001037695,0.0001741008,0.001382903],"genre_scores_gemma":[0.9956357,0.0001177335,0.003748012,0.00003814134,0.000004737655,0.00001510573,0.00007530682,0.00001945013,0.0003458881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00118037,"threshold_uncertainty_score":0.003948748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01429632159452045,"score_gpt":0.2270788226755293,"score_spread":0.2127825010810088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}