{"id":"W3161285197","doi":"10.1038/s41598-021-89745-9","title":"Beta cell adaptation to pregnancy requires prolactin action on both beta and non-beta cells","year":2021,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Calgary","funders":"Alberta Children's Hospital Foundation; Natural Sciences and Engineering Research Council of Canada; Magee-Womens Research Institute; Alberta Children's Hospital Research Institute; Children's Hospital Foundation","keywords":"Endocrinology; Internal medicine; Biology; Prolactin; Prolactin receptor; Beta cell; Genetically modified mouse; Transgene; Pancreatic islets; Insulin; Hormone; Gene; Islet; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001094308,0.0003098167,0.0001944207,0.0002082956,0.00008472083,0.0004190647,0.0001517674,0.0001451121,0.001212667],"category_scores_gemma":[0.0001296521,0.0001822331,0.0002810083,0.00009845702,0.0001606141,0.0001679537,0.0002359061,0.0006164396,0.0004095575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001338492,"about_ca_system_score_gemma":0.0001056008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002867174,"about_ca_topic_score_gemma":0.0002797841,"domain_scores_codex":[0.9998337,0.00002067752,0.00001374579,0.00004771047,0.00004725276,0.00003696951],"domain_scores_gemma":[0.9998279,0.00001977565,0.00006074924,0.00002609383,0.00001725468,0.00004818712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007622366,0.00000530859,0.0005270069,0.00001071281,0.000002733065,0.00007342833,0.000007566579,0.000006140994,0.9985169,0.00002409861,0.0000126958,0.0007372742],"study_design_scores_gemma":[0.00003256355,0.0005740622,0.1278657,0.00002105511,0.00006561865,0.002386366,0.0001252753,0.0004310546,0.8643807,0.0001504595,0.00395306,0.00001397948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921396,0.001962065,0.003375296,0.0001056836,0.00004442169,0.00001277952,0.0004365418,0.0001129243,0.001810609],"genre_scores_gemma":[0.9911958,0.001785202,0.00170402,0.0001389997,0.00003347929,0.00003082804,0.0007069007,0.00005786811,0.004346923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001212667,"threshold_uncertainty_score":0.004056752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03123403600298481,"score_gpt":0.2730619592722514,"score_spread":0.2418279232692666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}