{"id":"W3161336068","doi":"10.1002/alz.12333","title":"Plasma amyloid β levels are driven by genetic variants near <i>APOE, BACE1, APP, PSEN2</i>: A genome‐wide association study in over 12,000 non‐demented participants","year":2021,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Heart, Lung, and Blood Institute; National Institute on Aging; Canadian Institutes of Health Research; National Center for Advancing Translational Sciences; Agence Nationale de la Recherche; National Human Genome Research Institute; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; School of Medicine, Boston University; Ministerie van Onderwijs, Cultuur en Wetenschap; Erasmus Medisch Centrum; European Commission; ZonMw","keywords":"Endophenotype; Apolipoprotein E; Genome-wide association study; Genetic association; Genetics; Biology; Alzheimer's disease; Gene; Disease; Internal medicine; Medicine; Neuroscience; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007949174,0.000544432,0.0004077686,0.0005360083,0.0008060137,0.0007519263,0.000401375,0.0006540035,0.001706159],"category_scores_gemma":[0.001608252,0.0004535224,0.0005036333,0.0007607591,0.0004294874,0.0002362509,0.0003645224,0.0005399213,0.0002349303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001855004,"about_ca_system_score_gemma":0.0002158938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005563904,"about_ca_topic_score_gemma":0.004659905,"domain_scores_codex":[0.9996181,0.00009627047,0.00003813769,0.0001580371,0.00005134308,0.00003812918],"domain_scores_gemma":[0.9994025,0.0001565162,0.0001810003,0.00008448122,0.00006540697,0.0001101552],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007923487,0.00009310844,0.9933524,0.00002081608,0.0003728195,0.0005409765,0.0003843246,0.00005209737,0.0031892,0.00003228112,0.0001033215,0.001066158],"study_design_scores_gemma":[0.00003474309,0.0001376006,0.9984978,0.000004815099,0.0001632709,0.0005605817,0.0001199567,0.0001043483,0.0001942684,0.00003738596,0.0001404047,0.000004716117],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996494,0.00006773054,0.0000659319,0.00001035822,0.000002295224,0.000004144794,0.0001087507,0.000002513235,0.00008894125],"genre_scores_gemma":[0.9995304,0.00003679294,0.00009483247,0.0000150184,0.000005037698,0.000007029351,0.0001534461,0.000002529951,0.0001548794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005563904,"threshold_uncertainty_score":0.01106304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03784637969941138,"score_gpt":0.3062468589185439,"score_spread":0.2684004792191325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}