{"id":"W3161351685","doi":"10.1038/s41591-021-01370-1","title":"Phase 1 randomized trial of a plant-derived virus-like particle vaccine for COVID-19","year":2021,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Transgenic Plants and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":316,"is_retracted":false,"has_abstract":true,"ca_institutions":"Medicago (Canada); McGill University Health Centre","funders":"Australian Government; McGill University Health Centre; McGill University; GlaxoSmithKline","keywords":"Immunogenicity; Medicine; Vaccination; Adverse effect; Interim analysis; Tolerability; Randomized controlled trial; Neutralizing antibody; Immunology; Virology; Virus-like particle; Reactogenicity; Virus; Antibody; Pharmacology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003863477,0.0001121826,0.000391887,0.00001961819,0.00005121566,0.000003124141,0.0001098147,0.0002008224,0.00009553372],"category_scores_gemma":[0.0009104351,0.00008034988,0.0001254294,0.0000950769,0.00007483438,0.000001530966,0.00001826027,0.000114848,7.228016e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006013691,"about_ca_system_score_gemma":0.0001592562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001282232,"about_ca_topic_score_gemma":0.00008199202,"domain_scores_codex":[0.9990972,0.00006612454,0.0003112857,0.0002541098,0.0001224952,0.0001488152],"domain_scores_gemma":[0.9992274,0.0001687795,0.000103435,0.0002699705,0.0000914574,0.0001389725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.244412,0.0002568511,0.000001590746,0.00002793766,0.0001002163,0.000003272333,0.00005096361,0.000002035552,0.7384906,0.0004336047,0.01581732,0.0004035521],"study_design_scores_gemma":[0.5140068,0.0003677666,0.000001923856,0.00000820172,0.000108835,0.00001187822,0.00003029886,0.00005100435,0.3205113,0.0001341538,0.1647089,0.00005896711],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9545217,0.00632088,0.02530484,0.01043604,0.0005018056,0.001648179,0.001043622,0.00002335238,0.0001995582],"genre_scores_gemma":[0.992406,0.0007222799,0.0004938124,0.003526216,0.0005543281,0.0001800742,0.001822936,0.00001234203,0.0002820376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4179793,"threshold_uncertainty_score":0.3276573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01728728025388369,"score_gpt":0.3406259581976628,"score_spread":0.3233386779437791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}