{"id":"W3161351685","doi":"10.1038/s41591-021-01370-1","title":"Phase 1 randomized trial of a plant-derived virus-like particle vaccine for COVID-19","year":2021,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Transgenic Plants and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":316,"is_retracted":false,"has_abstract":true,"ca_institutions":"Medicago (Canada); McGill University Health Centre","funders":"Australian Government; McGill University Health Centre; McGill University; GlaxoSmithKline","keywords":"Immunogenicity; Medicine; Vaccination; Adverse effect; Interim analysis; Tolerability; Randomized controlled trial; Neutralizing antibody; Immunology; Virology; Virus-like particle; Reactogenicity; Virus; Antibody; Pharmacology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002065944,0.001799618,0.00223186,0.0003488775,0.0005258414,0.001109347,0.0009510919,0.00199035,0.007290437],"category_scores_gemma":[0.001760074,0.0006397031,0.001105212,0.0002950426,0.001128749,0.0009502451,0.0003706457,0.00286407,0.001239553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001020776,"about_ca_system_score_gemma":0.001899283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001538191,"about_ca_topic_score_gemma":0.003219878,"domain_scores_codex":[0.9992347,0.0003655218,0.00003254544,0.0001735956,0.00006103178,0.0001327341],"domain_scores_gemma":[0.9988551,0.0002738867,0.0003003544,0.0001055712,0.0001166591,0.00034838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9770452,0.01203651,0.0004202663,0.0002184999,0.0003679927,0.00002601598,0.00003581028,0.0002020738,0.002872246,0.00009040705,0.0006895877,0.005995486],"study_design_scores_gemma":[0.8094021,0.1874301,0.001147995,0.00001580909,0.0002005843,0.00002020828,0.0000207482,0.0003393442,0.0005063118,0.0001554751,0.000749636,0.00001169134],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9764922,0.001829112,0.001275669,0.0006689503,0.000954784,0.01407872,0.001959275,0.0001880657,0.0025533],"genre_scores_gemma":[0.9655483,0.001646244,0.003102103,0.00177514,0.0005895979,0.01627487,0.002287638,0.00004691868,0.008729271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007290437,"threshold_uncertainty_score":0.02438891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01728728025388369,"score_gpt":0.3406259581976628,"score_spread":0.3233386779437791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}