{"id":"W3161360412","doi":"10.1128/jvi.00971-20","title":"Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome","year":2021,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Biology; Cell biology; Proteasome; Viral replication; Ubiquitin; Cell cycle; HEK 293 cells; CDC20; Cell Cycle Protein; Scaffold protein; Virology; Genetics; Cell culture; Cell; Virus; Anaphase; Gene; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001321817,0.0002505849,0.000135641,0.0002406993,0.0002105467,0.0003794938,0.0001253924,0.0001624186,0.0007189384],"category_scores_gemma":[0.0001395835,0.0001376121,0.0001154241,0.00008216569,0.0001686206,0.0001591354,0.0002127788,0.0003365682,0.0002874759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003598751,"about_ca_system_score_gemma":0.000184713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004169563,"about_ca_topic_score_gemma":0.0006370568,"domain_scores_codex":[0.9999037,0.00001422841,0.000005612029,0.00003051308,0.0000257326,0.0000202046],"domain_scores_gemma":[0.9999466,0.00001208032,0.0000179581,0.000005839779,0.000004918262,0.00001262758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006096849,0.000006045034,0.000275641,0.00002957743,0.000003077275,0.00007063019,0.00001066393,0.00005267836,0.9980595,0.0001609741,0.00002501593,0.001245264],"study_design_scores_gemma":[0.00000622711,0.00008137579,0.007305869,0.000004252558,0.00000628606,0.0006149745,0.00001695117,0.0009624527,0.9893293,0.0000864657,0.001583372,0.000002596898],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931988,0.002699158,0.002122502,0.0000647623,0.00001262441,0.00001343544,0.0001408739,0.0000385538,0.001709223],"genre_scores_gemma":[0.9959795,0.001124428,0.001169715,0.00002213548,0.000009016258,0.00001109329,0.0001842374,0.000009323398,0.001490412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007189384,"threshold_uncertainty_score":0.002611101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02838916904321013,"score_gpt":0.2801785967859789,"score_spread":0.2517894277427687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}