{"id":"W3161405791","doi":"10.1101/2021.05.15.444262","title":"Safety, immunogenicity and protection provided by unadjuvanted and adjuvanted formulations of recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in non-human primates","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Medicago (Canada)","funders":"","keywords":"Immunogenicity; Adjuvant; Medicine; Immunology; Immune system; Virology; Nasal administration","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000285751,0.0004484545,0.0002573853,0.0001943084,0.0001495942,0.0002658293,0.0002282706,0.0005066992,0.001042818],"category_scores_gemma":[0.0002182396,0.0001675899,0.0002215653,0.0000990671,0.000333308,0.0002413927,0.00009825425,0.0008356069,0.0003092277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002221339,"about_ca_system_score_gemma":0.0002515264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004932863,"about_ca_topic_score_gemma":0.0004739001,"domain_scores_codex":[0.9998343,0.00004216302,0.000009631403,0.00002725034,0.00004611822,0.00004045416],"domain_scores_gemma":[0.9998748,0.00002207525,0.00003936743,0.00001452668,0.0000174227,0.00003177242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00209156,0.0008246967,0.000318241,0.0000981481,0.00001805977,0.00007880895,0.0000768851,0.0002157738,0.9929833,0.0001099415,0.0001241138,0.003060437],"study_design_scores_gemma":[0.0006048754,0.0579246,0.007729024,0.00004295833,0.00009317351,0.0006166147,0.0001108142,0.001466872,0.9257125,0.0002293077,0.005451959,0.00001736902],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976323,0.0008307435,0.0006305217,0.00006608714,0.00003892291,0.00005625634,0.0001742251,0.00003202783,0.0005389366],"genre_scores_gemma":[0.9963637,0.0005948285,0.0006816003,0.00006048641,0.00002216261,0.00008311252,0.0004548663,0.00001053057,0.001728633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001042818,"threshold_uncertainty_score":0.003488541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02322374969551561,"score_gpt":0.2970581747525794,"score_spread":0.2738344250570638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}