{"id":"W3161420844","doi":"10.17863/cam.79953","title":"Common variants in breast cancer risk loci predispose to distinct tumor subtypes.","year":2021,"lang":"en","type":"preprint","venue":"Apollo (University of Cambridge)","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; University of British Columbia; Simon Fraser University; McGill University; Queen's University; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Royal Victoria Hospital; Centre hospitalier universitaire de Québec; St. Francis Xavier University; BC Cancer Agency; University of Toronto","funders":"Mailman School of Public Health, Columbia University; National Cancer Institute; Servicio Gallego de Salud; Universitätsklinikum Hamburg-Eppendorf; Canadian Institutes of Health Research; University of California, Irvine; University of North Carolina at Chapel Hill; Weill Cornell Medical College; Vanderbilt-Ingram Cancer Center; National Institutes of Health; Queen's University Belfast; Centro de Investigación Biomédica en Red de Cáncer; Universitätsklinikum Köln; Universität zu Köln; Pontificia Universidad Javeriana; Deutsches Krebsforschungszentrum; Clalit Health Services; Odense Universitetshospital; Harvard T.H. Chan School of Public Health; Karolinska Institutet; National Health and Medical Research Council; Oulun Yliopisto; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill; Deutsche Krebshilfe; University of Toronto; Johns Hopkins Bloomberg School of Public Health; University of Edinburgh; Queen's University; National Human Genome Research Institute; Cancer Council Victoria; School of Medicine, Vanderbilt University; University of Melbourne; School of Medicine, Stanford University; Institut National de la Santé et de la Recherche Médicale; Universität Heidelberg; Biocenter, University of Oulu; National Institute for Health and Care Research; Government of Canada; University of Southern California; Cancer Research UK; Génome Québec; Instituto de Investigación Sanitaria de Santiago de Compostela; Pomorski Uniwersytet Medyczny W Szczecinie; Associazione Italiana per la Ricerca sul Cancro; Genome Canada; Erasmus Universitair Medisch Centrum Rotterdam; European Commission; Université Laval; Helsingin Yliopisto; Medical Research Council; Uppsala Universitet; University of California, San Diego; Johns Hopkins University; Memorial Sloan-Kettering Cancer Center; Fondation du cancer du sein du Québec; Centre Hospitalier Universitaire de Québec; Manchester Biomedical Research Centre; Monash University; University of Wisconsin-Milwaukee; Ovarian Cancer Research Fund; McGill University; Breast Cancer Research Foundation; Lunds Universitet; King's College London; Vanderbilt University; Stanford Cancer Institute; Cancer Research Institute","keywords":"Breast cancer; Genome-wide association study; Estrogen receptor; Biology; Oncology; Cancer; Genetic association; Logistic regression; Internal medicine; Genetics; Single-nucleotide polymorphism; Medicine; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003116419,0.0006620598,0.0007385222,0.001135234,0.0004813564,0.0009603776,0.000700138,0.0009664006,0.005063224],"category_scores_gemma":[0.009213861,0.0004197641,0.001512974,0.002353344,0.0008714035,0.00034354,0.0008289069,0.0009543224,0.0004688856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003754472,"about_ca_system_score_gemma":0.0005286902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003346593,"about_ca_topic_score_gemma":0.003316205,"domain_scores_codex":[0.9978955,0.0005284147,0.0001975799,0.0008998461,0.000274441,0.0002041905],"domain_scores_gemma":[0.9923354,0.004509709,0.001827262,0.0009146918,0.0001446999,0.0002682079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002220536,0.00008301569,0.9602772,0.0001900873,0.002324466,0.001930335,0.0002857334,0.001617718,0.01018767,0.000946391,0.000901631,0.01903521],"study_design_scores_gemma":[0.0003119035,0.0001938852,0.9789577,0.00005047307,0.001988093,0.004522078,0.0001218383,0.005473509,0.00257925,0.004318579,0.001451776,0.00003091669],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985464,0.001844795,0.008654208,0.000315677,0.0000352586,0.00004746035,0.002420064,0.0002520036,0.0009664746],"genre_scores_gemma":[0.9958836,0.0002546808,0.002349036,0.00007914338,0.00002781821,0.00002953674,0.0009768677,0.00004469559,0.0003546202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005063224,"threshold_uncertainty_score":0.01693821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007398745037230215,"score_gpt":0.2324306309430558,"score_spread":0.2250318859058256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}