{"id":"W3161425918","doi":"10.1038/s41586-021-03534-y","title":"In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates","year":2021,"lang":"en","type":"article","venue":"Nature","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":768,"is_retracted":false,"has_abstract":false,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"","keywords":"CRISPR; PCSK9; Gene knockdown; Genome editing; In vivo; Biology; Genetic enhancement; Cholesterol; Gene; Cancer research; Computational biology; Bioinformatics; Genetics; LDL receptor; Lipoprotein; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00310465395454611,"score_gpt":0.2779303889459633,"score_spread":0.2748257349914172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}