{"id":"W3161427556","doi":"10.1371/journal.pgen.1009516","title":"RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain","year":2021,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; NOVARTIS Foundation (Japan) for the Promotion of Science; Astellas Foundation for Research on Metabolic Disorders; Osaka Medical Research Foundation for Intractable Diseases; Ministry of Education, Culture, Sports, Science and Technology; Astellas Pharma; Japan Society for the Promotion of Science; Mochida Memorial Foundation for Medical and Pharmaceutical Research; Tokyo Biochemical Research Foundation; Japan Agency for Medical Research and Development; Uehara Memorial Foundation; Takeda Science Foundation; Naito Foundation","keywords":"ADAR; RNA editing; Biology; RNA; Gene isoform; MDA5; RNA-binding protein; Molecular biology; Adenosine deaminase; Knockout mouse; Gene expression; Cell biology; Genetics; Gene; Adenosine; RNA interference; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007742441,0.00007802076,0.00007184054,0.00002124538,0.00003406638,0.00001445681,0.00009591239,0.00005798309,0.00007875598],"category_scores_gemma":[0.0001943193,0.00006774723,0.00004993881,0.0001448229,0.00001793953,0.000001437782,0.00009550491,0.00003208478,0.00000985627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001553184,"about_ca_system_score_gemma":0.00004259611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001456742,"about_ca_topic_score_gemma":0.00002630874,"domain_scores_codex":[0.9992706,0.00007678132,0.0001711163,0.0001845744,0.0001749666,0.0001219731],"domain_scores_gemma":[0.9994849,0.00002233208,0.00005907873,0.0002765867,0.0001060924,0.000051002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002309136,0.0003222248,0.01150025,0.00001898484,0.00001571657,0.00000109236,0.0005061012,0.0005672253,0.9816268,0.00001942381,0.005237311,0.0001617948],"study_design_scores_gemma":[0.0002043848,0.00004129619,0.005285627,0.00001110411,0.000009573148,0.0000016286,0.0002639924,0.0009635862,0.9898254,0.00001578389,0.003299071,0.00007853472],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976351,0.0001058073,0.0001099751,0.00152226,0.00001840032,0.000159554,0.00002035508,0.000003619118,0.0004249797],"genre_scores_gemma":[0.9965728,0.00001759852,0.0003481396,0.002017297,0.00009924949,0.00001509194,0.00015756,0.00001083671,0.0007614198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008198638,"threshold_uncertainty_score":0.2762652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01849276586805872,"score_gpt":0.2701094133294336,"score_spread":0.2516166474613749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}