{"id":"W3161427556","doi":"10.1371/journal.pgen.1009516","title":"RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain","year":2021,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; NOVARTIS Foundation (Japan) for the Promotion of Science; Astellas Foundation for Research on Metabolic Disorders; Osaka Medical Research Foundation for Intractable Diseases; Ministry of Education, Culture, Sports, Science and Technology; Astellas Pharma; Japan Society for the Promotion of Science; Mochida Memorial Foundation for Medical and Pharmaceutical Research; Tokyo Biochemical Research Foundation; Japan Agency for Medical Research and Development; Uehara Memorial Foundation; Takeda Science Foundation; Naito Foundation","keywords":"ADAR; RNA editing; Biology; RNA; Gene isoform; MDA5; RNA-binding protein; Molecular biology; Adenosine deaminase; Knockout mouse; Gene expression; Cell biology; Genetics; Gene; Adenosine; RNA interference; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002167143,0.000746221,0.0005048083,0.0007348312,0.0002446003,0.0004985753,0.0005482652,0.0006753455,0.001548627],"category_scores_gemma":[0.0001535072,0.0004857696,0.0005792196,0.0001836229,0.000462608,0.0004519265,0.0003382454,0.001400613,0.0006517597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003966987,"about_ca_system_score_gemma":0.0002940791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005768759,"about_ca_topic_score_gemma":0.0009552389,"domain_scores_codex":[0.9995921,0.00003038143,0.00005364706,0.0001539898,0.00008589125,0.00008393167],"domain_scores_gemma":[0.9996696,0.00002600926,0.0001363512,0.00003689733,0.00002538263,0.000105841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008065249,0.00002456311,0.00008399955,0.00002661202,0.000007836653,0.00004708121,0.00001025693,0.00002151653,0.9989133,0.00009340473,0.00002949188,0.0006613091],"study_design_scores_gemma":[0.00004064284,0.0004308877,0.002320479,0.00001429127,0.00005865845,0.0004958009,0.00002393062,0.0006338165,0.993291,0.0000881376,0.00259403,0.000008421613],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836691,0.002667869,0.009410664,0.000277063,0.00007129185,0.00009152221,0.000979019,0.0005212782,0.002312175],"genre_scores_gemma":[0.9818869,0.00196953,0.00732937,0.0001968022,0.00003204419,0.0001839044,0.001600707,0.0001756744,0.006625018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001548627,"threshold_uncertainty_score":0.005180657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01849276586805872,"score_gpt":0.2701094133294336,"score_spread":0.2516166474613749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}