{"id":"W3161448988","doi":"10.3389/fonc.2021.672287","title":"Clinical Relevance of ABCB1, ABCG2, and ABCC2 Gene Polymorphisms in Chronic Myeloid Leukemia Patients Treated With Nilotinib","year":2021,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Nilotinib; Abcg2; Single-nucleotide polymorphism; Dasatinib; Multidrug resistance-associated protein 2; Pharmacogenetics; Genotype; Myeloid leukemia; Internal medicine; ATP-binding cassette transporter; Medicine; Tyrosine-kinase inhibitor; Pharmacology; Genetics; Oncology; Imatinib; Biology; Transporter; Gene; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000345783,0.0003060253,0.001317819,0.0002750299,0.00003109473,0.000005127924,0.0001340843,0.0004588173,0.00007509755],"category_scores_gemma":[0.0003268459,0.000272389,0.00009272145,0.0005796526,0.0004607475,0.00008682849,0.0001049878,0.0005826899,0.000008263152],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.007168677,"about_ca_system_score_gemma":0.003869523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003157103,"about_ca_topic_score_gemma":0.0006968303,"domain_scores_codex":[0.9971157,0.0003004888,0.001004813,0.0007524379,0.0002714057,0.0005551662],"domain_scores_gemma":[0.9985328,0.0002694016,0.0003256848,0.0005300177,0.0001392311,0.0002029074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001512602,0.0006923947,0.9333663,0.00006708726,0.0001963227,0.001071987,0.0001996312,0.00003868354,0.0007257574,0.00001260829,0.001653767,0.06046287],"study_design_scores_gemma":[0.03693938,0.004061169,0.9448255,0.0003637006,0.0001887577,0.0001466339,0.000102429,0.0006797903,0.003834725,0.0000644777,0.008528423,0.0002650328],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918286,0.004890047,0.0001077785,0.0002732932,0.0005013494,0.0006461145,0.00002394611,0.00003176649,0.001697114],"genre_scores_gemma":[0.9746529,0.003959238,0.01947389,0.0003423056,0.0001403013,0.0000706877,0.0001787553,0.0000588958,0.001123047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06019784,"threshold_uncertainty_score":0.9999728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01558706461041151,"score_gpt":0.2976799333228173,"score_spread":0.2820928687124058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}