{"id":"W3161448988","doi":"10.3389/fonc.2021.672287","title":"Clinical Relevance of ABCB1, ABCG2, and ABCC2 Gene Polymorphisms in Chronic Myeloid Leukemia Patients Treated With Nilotinib","year":2021,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Nilotinib; Abcg2; Single-nucleotide polymorphism; Dasatinib; Multidrug resistance-associated protein 2; Pharmacogenetics; Genotype; Myeloid leukemia; Internal medicine; ATP-binding cassette transporter; Medicine; Tyrosine-kinase inhibitor; Pharmacology; Genetics; Oncology; Imatinib; Biology; Transporter; Gene; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002900599,0.0002006109,0.0003714509,0.0003693658,0.0003458683,0.0003804181,0.0001450703,0.000401898,0.001182337],"category_scores_gemma":[0.0009701845,0.0001265591,0.0002697377,0.0006504764,0.0003715524,0.0001789013,0.0001630687,0.0004207348,0.000133446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002306081,"about_ca_system_score_gemma":0.000229543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001691476,"about_ca_topic_score_gemma":0.001935289,"domain_scores_codex":[0.9996239,0.00009856851,0.00004204888,0.0001163071,0.00006362338,0.00005552326],"domain_scores_gemma":[0.9995835,0.0001163037,0.0001493343,0.00002628717,0.0000412583,0.00008330616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009772236,0.0000795372,0.9879781,0.00002231352,0.00009661136,0.0005092471,0.0001037237,0.0001110058,0.00534078,0.00005281082,0.0001166336,0.004612016],"study_design_scores_gemma":[0.00005970913,0.0002162739,0.9974236,0.000004893694,0.0001027966,0.0008393486,0.00009558477,0.0002799513,0.0004361973,0.0001048734,0.0004309436,0.000005912173],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992259,0.0003295837,0.00004487404,0.00004537257,0.000004574411,0.000004520306,0.00007553255,0.000001269348,0.0002684538],"genre_scores_gemma":[0.9997012,0.00005680669,0.00003111853,0.00003888904,0.000007230768,0.000004476868,0.00007074665,0.000001014709,0.00008845379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001691476,"threshold_uncertainty_score":0.003955364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01558706461041151,"score_gpt":0.2976799333228173,"score_spread":0.2820928687124058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}