{"id":"W3161491831","doi":"10.1172/jci.insight.145523","title":"Nanocarrier-enhanced intracellular delivery of benznidazole for treatment of Trypanosoma cruzi infection","year":2021,"lang":"en","type":"article","venue":"JCI Insight","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; University of California, Los Angeles; National Institutes of Health; Northwestern University","keywords":"Benznidazole; Trypanosoma cruzi; Nanocarriers; Chagas disease; Parasitemia; Intracellular; Nifurtimox; Pharmacology; Medicine; Biology; Virology; Immunology; Drug; Biochemistry; Parasite hosting; Plasmodium falciparum","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001140318,0.0001866864,0.0002065335,0.0001248787,0.00007570034,0.0001608017,0.0001272599,0.0002430516,0.0005264407],"category_scores_gemma":[0.00008712748,0.00007876183,0.0001355971,0.00007584239,0.0001457482,0.0001974946,0.0001307081,0.0002838035,0.0001442205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003136254,"about_ca_system_score_gemma":0.0001824221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001365851,"about_ca_topic_score_gemma":0.002238744,"domain_scores_codex":[0.9999473,0.000008541666,0.00000334974,0.00001177848,0.00001812999,0.00001092999],"domain_scores_gemma":[0.9999763,0.00000535896,0.000006739743,0.000001902299,0.000004740853,0.000004849985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003789727,0.00001427709,0.00002642552,0.00002409458,0.000002755735,0.00001834696,0.000007803967,0.00009910029,0.9977236,0.00005455979,0.00003246605,0.001958538],"study_design_scores_gemma":[0.00003496277,0.000362619,0.0008224084,0.000004616519,0.00001497196,0.0001030979,0.000008198915,0.001997572,0.9945978,0.00002160825,0.002027705,0.000004527067],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9780194,0.004284983,0.01456169,0.0003074119,0.00007867476,0.00009483744,0.0001645163,0.0001414936,0.002346889],"genre_scores_gemma":[0.9855645,0.001781041,0.01062967,0.00008493438,0.00001389303,0.00003720728,0.0001012791,0.00001910148,0.001768475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001365851,"threshold_uncertainty_score":0.002715766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03660251658092132,"score_gpt":0.3125572783855497,"score_spread":0.2759547618046284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}