{"id":"W3161543281","doi":"10.1038/s41467-021-23186-w","title":"RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"National Center for Advancing Translational Sciences; Conquer Cancer Foundation; Institut Gustave-Roussy; Austrian Science Fund; Georgia Clinical and Translational Science Alliance; Ligue Contre le Cancer; American Society of Clinical Oncology; National Institutes of Health; Henry J. Predolin Foundation for Research in Leukemia; University of Wisconsin Carbone Cancer Center; National Cancer Institute; Institut National Du Cancer","keywords":"Chronic myelomonocytic leukemia; Cancer research; Biology; PLK1; Myeloid leukemia; Histone H3; NPM1; Epigenetics; Mutation; Methyltransferase; Leukemia; Decitabine; Histone; Methylation; DNA methylation; Molecular biology; Gene; Genetics; Cell cycle; Gene expression; Immunology; Bone marrow; Myelodysplastic syndromes","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0003147644,0.00028641,0.0004552458,0.0002676619,0.0007106866,0.00008138469,0.0009551896,0.0005733802,0.0003561944],"category_scores_gemma":[0.001257784,0.0002759747,0.0002153322,0.001366466,0.0005215943,0.000223504,0.0007669162,0.003656908,0.0004843167],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.004037273,"about_ca_system_score_gemma":0.006251031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006899136,"about_ca_topic_score_gemma":0.001168375,"domain_scores_codex":[0.997582,0.0004370734,0.0004658553,0.000498431,0.000507459,0.0005091353],"domain_scores_gemma":[0.9937833,0.0008265791,0.0001392761,0.003639348,0.001300259,0.0003112682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008122807,0.004117616,0.02579997,0.001110496,0.006313117,0.0016037,0.02189796,0.000746667,0.42571,0.1653664,0.2304292,0.1160926],"study_design_scores_gemma":[0.01345265,0.001031605,0.08386391,0.0009378138,0.001560616,0.003094662,0.004236815,0.08524197,0.1124664,0.006009065,0.6861885,0.001916044],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.3448704,0.1417518,0.01229281,0.2685443,0.001266894,0.01035807,0.0006375483,0.002161765,0.2181164],"genre_scores_gemma":[0.9697393,0.001903205,0.01968705,0.001791096,0.0002538378,0.0004435861,0.001494751,0.0000680068,0.004619226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6248688,"threshold_uncertainty_score":0.9999692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02499164816460027,"score_gpt":0.3482445861579107,"score_spread":0.3232529379933105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}