{"id":"W3161543281","doi":"10.1038/s41467-021-23186-w","title":"RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"National Center for Advancing Translational Sciences; Conquer Cancer Foundation; Institut Gustave-Roussy; Austrian Science Fund; Georgia Clinical and Translational Science Alliance; Ligue Contre le Cancer; American Society of Clinical Oncology; National Institutes of Health; Henry J. Predolin Foundation for Research in Leukemia; University of Wisconsin Carbone Cancer Center; National Cancer Institute; Institut National Du Cancer","keywords":"Chronic myelomonocytic leukemia; Cancer research; Biology; PLK1; Myeloid leukemia; Histone H3; NPM1; Epigenetics; Mutation; Methyltransferase; Leukemia; Decitabine; Histone; Methylation; DNA methylation; Molecular biology; Gene; Genetics; Cell cycle; Gene expression; Immunology; Bone marrow; Myelodysplastic syndromes","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001039451,0.0003532269,0.00014298,0.0003119926,0.0001809832,0.0004506073,0.0001543266,0.0002687256,0.002120341],"category_scores_gemma":[0.0001018424,0.0001708254,0.0001782762,0.0001701355,0.0003220101,0.0001556823,0.0002971262,0.000607097,0.0005602014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003968278,"about_ca_system_score_gemma":0.000205609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004243102,"about_ca_topic_score_gemma":0.0009930161,"domain_scores_codex":[0.9998419,0.00001905583,0.00001180709,0.00003911443,0.00005517955,0.00003291391],"domain_scores_gemma":[0.999884,0.00001766252,0.0000456374,0.0000117999,0.000006334128,0.00003458199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001274033,0.00004246028,0.000663008,0.00001958387,0.000004467141,0.00008039999,0.000009512846,0.00009859572,0.9972941,0.0002098208,0.0001129896,0.001337536],"study_design_scores_gemma":[0.00006467715,0.0005178267,0.01513264,0.000008748869,0.00001938953,0.001156544,0.00005969804,0.002090495,0.9747035,0.0002391343,0.006000027,0.000007316133],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945349,0.0005699627,0.001477743,0.0002443898,0.00002944232,0.00002908394,0.00107506,0.0002638286,0.001775731],"genre_scores_gemma":[0.9968478,0.0002532867,0.0007573643,0.00006327816,0.000006297669,0.00002473213,0.0004836474,0.00002402123,0.00153965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002120341,"threshold_uncertainty_score":0.007093251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02499164816460027,"score_gpt":0.3482445861579107,"score_spread":0.3232529379933105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}