{"id":"W3161543598","doi":"10.1126/scitranslmed.abd1869","title":"ABCB10 exports mitochondrial biliverdin, driving metabolic maladaptation in obesity","year":2021,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Clinical and Translational Science Institute, University of California, Los Angeles; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; National Institute on Alcohol Abuse and Alcoholism; Takeda Canada; University of California, Los Angeles; National Institutes of Health; American Heart Association; Universidade de Santiago de Compostela; Innovative Medicines Initiative; National Center for Advancing Translational Sciences; Wellcome Trust; Boston Nutrition Obesity Research Center, Boston University; Canadian Diabetes Association; Wellcome Trust Centre for Mitochondrial Research; Tourettes Action","keywords":"Biliverdin; Biliverdin reductase; Bilirubin; Biochemistry; Mitochondrion; Biology; Steatosis; Heme; Chemistry; Cell biology; Endocrinology; Heme oxygenase; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001780192,0.0003385071,0.0002628428,0.0002103479,0.0002060025,0.0004220721,0.0001692138,0.0004007289,0.001352131],"category_scores_gemma":[0.0001664336,0.0002234159,0.0002324272,0.000169183,0.0003015636,0.000259692,0.0002500849,0.0007851604,0.0004870605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003480648,"about_ca_system_score_gemma":0.0001977872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007462121,"about_ca_topic_score_gemma":0.0007696295,"domain_scores_codex":[0.999862,0.00002150177,0.00001282261,0.000040619,0.00003332633,0.00002963709],"domain_scores_gemma":[0.9998735,0.000008350346,0.00003721616,0.00001063993,0.00002180323,0.00004847435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002600741,0.00002347234,0.0008565888,0.00006663121,0.000006687832,0.0001239814,0.00001697312,0.00003962347,0.9969296,0.0001845307,0.0001063165,0.001385598],"study_design_scores_gemma":[0.0001515609,0.0007894074,0.05269249,0.00005304422,0.00009767254,0.002592954,0.0003063978,0.002716219,0.9253204,0.0007448858,0.01450623,0.00002876038],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916443,0.002558996,0.003400301,0.0006626549,0.00009507163,0.0000224067,0.0003597208,0.0001376785,0.001118868],"genre_scores_gemma":[0.9931841,0.001446521,0.001468721,0.0001989641,0.0000185867,0.000041809,0.0005022136,0.00003459714,0.003104497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001352131,"threshold_uncertainty_score":0.004523337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01157512705747982,"score_gpt":0.2680300576716971,"score_spread":0.2564549306142173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}