{"id":"W3161597249","doi":"10.1038/s41598-021-89476-x","title":"Portrait of DNA methylated genes predictive of poor prognosis in head and neck cancer and the implication for targeted therapy","year":2021,"lang":"en","type":"review","venue":"Scientific Reports","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; Global Affairs Canada; Réseau de Recherche en Santé Buccodentaire et Osseuse","keywords":"DNA methylation; Medicine; Oncology; Epigenetics; CDH1; Cancer; Internal medicine; CD44; Cancer research; Bioinformatics; Gene; Biology; Cell; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002007594,0.0002573897,0.001514637,0.004365904,0.0001535833,0.0007406394,0.0003806999,0.0003852542,0.0007350722],"category_scores_gemma":[0.006488042,0.0001745971,0.001892402,0.003977227,0.0003108674,0.0005205336,0.0003286516,0.0003122167,0.0000808492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005727147,"about_ca_system_score_gemma":0.001463062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003228076,"about_ca_topic_score_gemma":0.007842595,"domain_scores_codex":[0.9991108,0.0002513335,0.0002539961,0.0001912964,0.0001650171,0.00002759689],"domain_scores_gemma":[0.9950988,0.003352517,0.0009927409,0.0001220014,0.0003884,0.00004551298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009691931,0.00003635338,0.09001321,0.3687945,0.02483911,0.0005819264,0.0007799428,0.001155436,0.01050692,0.00122707,0.004100751,0.4969956],"study_design_scores_gemma":[0.0003456977,0.0009698071,0.433755,0.2526244,0.1737643,0.004809302,0.001486763,0.001291241,0.006435766,0.003680588,0.1207009,0.0001362789],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01310693,0.9851656,0.0002747732,0.0004273095,0.00004206343,0.00001784924,0.0006775739,0.000005085122,0.0002828125],"genre_scores_gemma":[0.1696774,0.8268636,0.001242429,0.0007527953,0.000107888,0.00007282042,0.00101685,0.000007897608,0.0002583196],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004365904,"threshold_uncertainty_score":0.01061726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03081952282522828,"score_gpt":0.338409242345671,"score_spread":0.3075897195204427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}