{"id":"W3161597300","doi":"10.1016/j.jpsychires.2021.05.015","title":"Increased levels of circulating cell-free mtDNA in plasma of late life depression subjects","year":2021,"lang":"en","type":"article","venue":"Journal of Psychiatric Research","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Institute of Mental Health; National Alliance for Research on Schizophrenia and Depression; Brain and Behavior Research Foundation","keywords":"Oxidative stress; Mitochondrial DNA; Depression (economics); Mitochondrion; Internal medicine; Pathophysiology; Medicine; Endocrinology; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001471236,0.00008204985,0.0002625725,0.0003465956,0.00004056931,0.000008752741,0.0002813443,0.000188282,0.0001073488],"category_scores_gemma":[0.001691163,0.00007236427,0.0001438779,0.0005539207,0.0000538255,0.000005121156,0.0001439702,0.0003779229,0.000001756006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001333026,"about_ca_system_score_gemma":0.0007158426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004178171,"about_ca_topic_score_gemma":0.00004407822,"domain_scores_codex":[0.9978559,0.0006398846,0.0006511038,0.0001795356,0.0004545486,0.0002190159],"domain_scores_gemma":[0.9984149,0.0001356107,0.0003557061,0.0003406634,0.0006282757,0.0001248868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004960366,0.0001700887,0.0690103,0.0001026732,0.00002437463,0.00004080289,0.00006690723,0.0002061415,0.9272502,0.00001839458,0.001997605,0.0006164865],"study_design_scores_gemma":[0.005102293,0.0009224621,0.085361,0.0001005554,0.00002510006,0.0001595385,0.0003458644,0.000127563,0.9060916,0.0005791549,0.001047014,0.0001379046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944366,0.002104652,0.0004698178,0.000163117,0.0004135001,0.00008051957,0.00001085619,8.939928e-7,0.002320093],"genre_scores_gemma":[0.9950298,0.0003467957,0.0040426,0.00002974617,0.0003496858,0.000001321655,0.000004676158,0.00001196358,0.0001834292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02115863,"threshold_uncertainty_score":0.2950929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04588709756345236,"score_gpt":0.3376660676444075,"score_spread":0.2917789700809551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}