{"id":"W3161644370","doi":"10.3390/genes12050723","title":"New Insights into the Therapeutic Applications of CRISPR/Cas9 Genome Editing in Breast Cancer","year":2021,"lang":"en","type":"review","venue":"Genes","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Terry Fox Foundation","keywords":"CRISPR; Genome editing; Breast cancer; Computational biology; Cas9; Genome; Biology; Cancer; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007151427,0.0002164267,0.000450513,0.00004992502,0.00004203085,0.00001566708,0.000303554,0.0001874902,0.00003135268],"category_scores_gemma":[0.000004184499,0.0001568878,0.0001990829,0.0002503861,0.00002917724,0.000001227312,0.000132323,0.0001229952,0.000002972556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002042129,"about_ca_system_score_gemma":0.0002871542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001522409,"about_ca_topic_score_gemma":0.0002399323,"domain_scores_codex":[0.9990596,0.00005002101,0.0003270698,0.000310021,0.00008991609,0.0001634338],"domain_scores_gemma":[0.9993212,0.00001748843,0.0001165098,0.0004463743,0.00005429903,0.00004416604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[7.308411e-7,0.00001063378,0.00001422103,0.001100722,0.000107194,7.907427e-7,0.0001030293,0.000126891,0.003121676,0.00002847948,0.00009973892,0.9952859],"study_design_scores_gemma":[0.00005781947,0.000007565934,0.00005189091,0.0004729233,0.0001407104,0.00001603591,0.00006606668,0.000003648839,0.001223158,0.00001528752,0.9977796,0.000165274],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004254436,0.9908707,0.008466824,0.00005728159,0.0001473404,0.0003291363,0.00002039486,0.000004873294,0.00006091591],"genre_scores_gemma":[0.000550929,0.9974141,0.0002705365,0.00003540634,0.00111698,0.0002394465,0.0001319345,0.00003676701,0.0002039012],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9976799,"threshold_uncertainty_score":0.6397699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01573348700480573,"score_gpt":0.3439116274347458,"score_spread":0.3281781404299401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}