{"id":"W3161644370","doi":"10.3390/genes12050723","title":"New Insights into the Therapeutic Applications of CRISPR/Cas9 Genome Editing in Breast Cancer","year":2021,"lang":"en","type":"review","venue":"Genes","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Terry Fox Foundation","keywords":"CRISPR; Genome editing; Breast cancer; Computational biology; Cas9; Genome; Biology; Cancer; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003691405,0.0005245201,0.0007932573,0.001618809,0.0001957663,0.0006458022,0.0005220076,0.0007509846,0.002249985],"category_scores_gemma":[0.0003724662,0.0001944772,0.000537092,0.001139558,0.0002595982,0.0006670118,0.0003971862,0.001479559,0.0009952713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000428284,"about_ca_system_score_gemma":0.0006418732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006226351,"about_ca_topic_score_gemma":0.001100686,"domain_scores_codex":[0.9998535,0.00002499759,0.00002011462,0.00002483819,0.00005786817,0.00001859906],"domain_scores_gemma":[0.9998797,0.00006345398,0.0000139446,0.000004308735,0.0000275124,0.00001108081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007224418,0.00007970739,0.0001434908,0.01980728,0.0000998895,0.0004389533,0.00008911638,0.0007142823,0.01252982,0.006374366,0.02069926,0.9389517],"study_design_scores_gemma":[0.00001728068,0.0001280335,0.0006778041,0.002120873,0.0001177772,0.002054246,0.00004052795,0.0002131881,0.003088149,0.001995801,0.9895239,0.0000223937],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003646251,0.996574,0.0006365746,0.0003092388,0.0001959035,0.000008292036,0.00003522733,0.00002397669,0.001852151],"genre_scores_gemma":[0.001861586,0.9964318,0.0005602806,0.0002253579,0.00008182794,0.000009353082,0.00005135279,0.000003334585,0.0007750573],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002249985,"threshold_uncertainty_score":0.007526934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01573348700480573,"score_gpt":0.3439116274347458,"score_spread":0.3281781404299401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}