{"id":"W3161658709","doi":"10.1038/s41592-021-01169-5","title":"Diversity in immunogenomics: the value and the challenge","year":2021,"lang":"en","type":"article","venue":"Nature Methods","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":79,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"National Cancer Institute; National Institute on Aging; University of California, San Diego; Fogarty International Center; University of California, Los Angeles; Tsinghua Shenzhen International Graduate School; School of Pharmacy, University of Southern California; Directorate for Biological Sciences; National Institutes of Health; Bill and Melinda Gates Foundation; Karolinska Institutet; Pirogov Russian National Research Medical University; National Human Genome Research Institute; Universitetet i Oslo; Centre National de la Recherche Scientifique; Simon Fraser University; Universidad de Tarapacá; Dr. Ralph and Marian Falk Medical Research Trust; Tsinghua University; Ministry of Science and Higher Education of the Russian Federation; Beckman Research Institute, City of Hope; University of Southern California; National Institute of Allergy and Infectious Diseases; Russian Academy of Sciences; Agence Nationale de la Recherche; Norges Forskningsråd; James S. McDonnell Foundation; Arizona Biomedical Research Commission; David Geffen School of Medicine, University of California, Los Angeles; National Science Foundation; Bar-Ilan University; Science for Life Laboratory; Vetenskapsrådet; Mayo Clinic; University of Louisville; U.S. Department of Defense","keywords":"Diversity (politics); Biology; Evolutionary biology; Human genetic variation; Variation (astronomy); Value (mathematics); Adaptive value; Inclusion (mineral); Immune system; Computational biology; Immunology; Genetics; Psychology; Human genome; Computer science; Sociology; Gene; Social psychology; Genome; Anthropology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03230542,0.0008845524,0.003548282,0.002273391,0.001824032,0.00558263,0.003280127,0.003956589,0.003806689],"category_scores_gemma":[0.02763683,0.0008821565,0.001006047,0.001830199,0.00943183,0.01280979,0.007995105,0.01115618,0.001332782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001767971,"about_ca_system_score_gemma":0.001872733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000745933,"about_ca_topic_score_gemma":0.001335515,"domain_scores_codex":[0.9858527,0.007926348,0.000403506,0.001588532,0.003591723,0.0006372197],"domain_scores_gemma":[0.9616928,0.02648419,0.001240657,0.006911029,0.00234251,0.001328783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0008268799,0.0004835797,0.02402426,0.004404354,0.0009547975,0.0004134262,0.003198566,0.005776019,0.08231822,0.4046088,0.03353196,0.4394591],"study_design_scores_gemma":[0.00009249874,0.0004565616,0.009640269,0.0008387007,0.0001872709,0.001468561,0.001813235,0.01170768,0.01303289,0.8075483,0.1530403,0.0001736793],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1149983,0.2384461,0.482758,0.1270437,0.006719474,0.000297642,0.002232027,0.001343187,0.02616159],"genre_scores_gemma":[0.6270601,0.09705876,0.2109396,0.04218464,0.01224922,0.001131035,0.001665612,0.0007901764,0.006920923],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.03230542,"threshold_uncertainty_score":0.1708494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01950652122537632,"score_gpt":0.3129782575299208,"score_spread":0.2934717363045445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}