{"id":"W3161673430","doi":"10.3389/fphys.2021.674254","title":"Natriuretic Peptide Clearance Receptor (NPR-C) Pathway as a Novel Therapeutic Target in Obesity-Related Heart Failure With Preserved Ejection Fraction (HFpEF)","year":2021,"lang":"en","type":"review","venue":"Frontiers in Physiology","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut du Savoir Montfort; Montfort Hospital; University of Ottawa","funders":"","keywords":"Heart failure; Heart failure with preserved ejection fraction; Ejection fraction; Natriuretic peptide; Medicine; Internal medicine; Cardiology; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004364334,0.0004070066,0.0007732773,0.0003304412,0.0002407718,0.0007564173,0.0005419455,0.0007340802,0.002250443],"category_scores_gemma":[0.0002728647,0.00009769146,0.0006166544,0.0002333518,0.0003485527,0.000493087,0.0004416959,0.002086721,0.0005182415],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003297026,"about_ca_system_score_gemma":0.0006823273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004204539,"about_ca_topic_score_gemma":0.001116907,"domain_scores_codex":[0.9998596,0.00003547411,0.0000097963,0.00002447122,0.00003075297,0.00003993409],"domain_scores_gemma":[0.9999136,0.00001478441,0.00002187216,0.000004859745,0.00001962097,0.00002527659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.008409858,0.002994692,0.004332595,0.005857901,0.0005939627,0.002042283,0.0002660319,0.001917727,0.1831739,0.01352481,0.02797565,0.7489105],"study_design_scores_gemma":[0.01187121,0.03166501,0.05823321,0.004914834,0.003095159,0.01213027,0.0008298929,0.01364386,0.09912155,0.01902646,0.7451091,0.0003593154],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1393333,0.8246934,0.008314444,0.01038944,0.002121599,0.0003265787,0.0004488569,0.0003127251,0.01405965],"genre_scores_gemma":[0.531447,0.4381734,0.01270569,0.007043338,0.001782411,0.0006003958,0.001155681,0.00005062105,0.007041572],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002250443,"threshold_uncertainty_score":0.007528424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01805173568875689,"score_gpt":0.2767968884116065,"score_spread":0.2587451527228496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}