{"id":"W3161677348","doi":"10.1101/2021.05.20.21257484","title":"Identification of shared and differentiating genetic risk for autism spectrum disorder, attention deficit hyperactivity disorder and case subgroups","year":2021,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Autism Spectrum Disorder Research","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Institute of Mental Health; Agència de Gestió d'Ajuts Universitaris i de Recerca; Horizon 2020 Framework Programme; Novo Nordisk Fonden; H. Lundbeck A/S; Lundbeckfonden; Ministerio de Economía y Competitividad; Novo Nordisk; Generalitat de Catalunya; Aarhus Universitet; European Commission; European College of Neuropsychopharmacology; Ministerio de Ciencia, Innovación y Universidades; National Alliance for Research on Schizophrenia and Depression","keywords":"Attention deficit hyperactivity disorder; Autism spectrum disorder; Genetic architecture; Autism; Neuroticism; Comorbidity; Neurodevelopmental disorder; Genome-wide association study; Psychology; Etiology; Clinical psychology; Psychiatry; Phenotype; Genetics; Single-nucleotide polymorphism; Gene; Biology; Personality; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001008236,0.0003807284,0.0004763281,0.001825061,0.0006028587,0.0008682908,0.0004108991,0.0005658244,0.002836149],"category_scores_gemma":[0.002927053,0.00016091,0.0006282503,0.000880415,0.0004142055,0.0002546226,0.0009975182,0.0004262213,0.0002678935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002884942,"about_ca_system_score_gemma":0.0002849822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002705592,"about_ca_topic_score_gemma":0.003086712,"domain_scores_codex":[0.9990346,0.0002183476,0.00008121055,0.0004327424,0.0001328257,0.0001002408],"domain_scores_gemma":[0.9990621,0.000344348,0.0002718549,0.000162546,0.00005585432,0.0001032582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007065508,0.0001198487,0.9170883,0.00006162713,0.0006694403,0.00288951,0.0008796538,0.0004623701,0.06158138,0.0008334354,0.001117354,0.01359073],"study_design_scores_gemma":[0.00003030522,0.0000789832,0.9863115,0.00002438353,0.0002667789,0.004110769,0.0004810619,0.001952326,0.004592159,0.001279982,0.0008573566,0.00001442489],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971113,0.0001612089,0.001365101,0.00008098196,0.000008210655,0.00001743761,0.0006629848,0.00003588898,0.0005568827],"genre_scores_gemma":[0.9973325,0.00005685989,0.001311286,0.00003363453,0.000007739633,0.00002428425,0.0009681016,0.00002477136,0.0002409174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002836149,"threshold_uncertainty_score":0.009487808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02809878092446564,"score_gpt":0.2929536369190802,"score_spread":0.2648548559946146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}