{"id":"W3161712813","doi":"10.1016/j.jpba.2021.114151","title":"A sensitive analytical method for the determination of SG-SP1 in rat plasma by HPLC-MS/MS and its application to a pharmacokinetic study","year":2021,"lang":"en","type":"article","venue":"Journal of Pharmaceutical and Biomedical Analysis","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Research Foundation of Korea; Ministry of Health and Welfare","keywords":"Chemistry; Protein precipitation; Chromatography; Pharmacokinetics; Formic acid; Bioanalysis; High-performance liquid chromatography; Tandem mass spectrometry; Acetonitrile; Bioavailability; Mass spectrometry; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00103994,0.0001244906,0.0005232883,0.000280491,0.0000726143,0.0000135281,0.00009943718,0.00009853307,0.000199322],"category_scores_gemma":[0.0001909668,0.00007746981,0.0001478191,0.0008222908,0.0001446406,0.00003779741,0.00007677075,0.0002633858,0.000001810349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002183802,"about_ca_system_score_gemma":0.0000352735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002292309,"about_ca_topic_score_gemma":0.00003264411,"domain_scores_codex":[0.9985469,0.0003047932,0.000605409,0.0002270986,0.0001261767,0.0001896423],"domain_scores_gemma":[0.9985238,0.0008628725,0.0001763061,0.00007006402,0.0002498631,0.0001170857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00094056,0.001402925,0.001233839,0.00007275291,0.001717312,0.00004306272,0.0006399687,0.00001425811,0.8127506,0.0001118129,0.0005080761,0.1805649],"study_design_scores_gemma":[0.01455721,0.002249395,0.01036339,0.00007409995,0.01707189,0.0004894705,0.002157744,0.3915471,0.4182846,0.0001234075,0.1425714,0.0005102562],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8503702,0.002813596,0.1395086,0.006572301,0.0001383102,0.0004789816,0.00007970262,0.000004541985,0.00003378432],"genre_scores_gemma":[0.9981802,0.0003351277,0.0008118849,0.0002922666,0.00005018547,0.00001287256,0.00002083925,0.000005047592,0.0002915746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.394466,"threshold_uncertainty_score":0.3159127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01872869324442729,"score_gpt":0.3501754538553679,"score_spread":0.3314467606109406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}