{"id":"W3161751952","doi":"10.2139/ssrn.3466981","title":"Predictive Markers of LRRK2 Inhibition in Biofluids","year":2019,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Atuka (Canada); Nexen (Canada)","funders":"","keywords":"Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006624521,0.0006673771,0.0005141866,0.0007306109,0.0002111799,0.001051582,0.0002601324,0.0006423497,0.002140847],"category_scores_gemma":[0.001348828,0.0001500929,0.0002857287,0.0004851188,0.0002626682,0.0006062043,0.0002971692,0.0009199143,0.0006806231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003740921,"about_ca_system_score_gemma":0.0002423326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003554923,"about_ca_topic_score_gemma":0.0004558579,"domain_scores_codex":[0.9995682,0.0000833466,0.00003827545,0.000079783,0.000186462,0.00004391307],"domain_scores_gemma":[0.9995456,0.0001395982,0.000157854,0.0000267072,0.00009710903,0.00003308033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005522303,0.0005623511,0.0142929,0.0007894117,0.0002305642,0.0004014903,0.0001669224,0.001679663,0.8530218,0.0009227881,0.001841343,0.1205685],"study_design_scores_gemma":[0.0001891471,0.006508424,0.04045621,0.0002795607,0.0006068926,0.001195779,0.0003057421,0.01038301,0.9278057,0.001532901,0.01066155,0.00007514365],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9148253,0.04867118,0.01931789,0.0008309053,0.0006876242,0.0002893674,0.002680612,0.0006560536,0.01204107],"genre_scores_gemma":[0.9828218,0.006086353,0.006130389,0.0003817797,0.0001234266,0.0002329665,0.00101203,0.00003108327,0.00318022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002140847,"threshold_uncertainty_score":0.007161856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005005028258560762,"score_gpt":0.2324365409649445,"score_spread":0.2274315127063838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}