{"id":"W3161786639","doi":"10.3390/cancers13102407","title":"Histone Acetyltransferases and Stem Cell Identity","year":2021,"lang":"en","type":"review","venue":"Cancers","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Calgary","funders":"Alberta Children's Hospital Research Institute","keywords":"Stem cell; Biology; Histone; Cell biology; Induced pluripotent stem cell; Epigenetics; Cellular differentiation; Epigenetic regulation of neurogenesis; Gene knockdown; Gene; Genetics; Embryonic stem cell; Histone methyltransferase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001593472,0.0003209468,0.0007968301,0.00007743142,0.00009737877,0.00004893176,0.000260876,0.0003763677,0.00004770435],"category_scores_gemma":[0.0000192211,0.0003202954,0.0003196665,0.0001853223,0.0001902674,0.000005083921,0.0001534807,0.0002931273,0.00002150785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006972593,"about_ca_system_score_gemma":0.002157728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008596553,"about_ca_topic_score_gemma":0.00009344863,"domain_scores_codex":[0.998321,0.0001720445,0.0003031879,0.0006632811,0.0002226003,0.0003178895],"domain_scores_gemma":[0.9991267,0.00002209364,0.00008850607,0.0005067626,0.00007927365,0.0001766892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001410406,0.0000294469,0.000001316505,0.01975932,0.000291258,0.0001168538,0.00006960792,0.000005038186,0.008382065,0.00003351758,0.04113143,0.9301661],"study_design_scores_gemma":[0.0001493637,0.00006032837,9.270496e-8,0.001393781,0.000156368,0.00004104212,0.00002955582,2.774325e-7,0.00735152,5.284346e-7,0.9905002,0.000316957],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000972231,0.9969738,0.00006818984,0.000005747706,0.0003306803,0.0003414681,0.0001590482,0.0000118078,0.001136999],"genre_scores_gemma":[0.0001173903,0.9925535,0.00003916671,0.00003312348,0.0003336683,0.0001095592,0.0004569745,0.00006910796,0.006287512],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9493688,"threshold_uncertainty_score":0.9999249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03465696435674875,"score_gpt":0.3617858967922059,"score_spread":0.3271289324354571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}