{"id":"W3161786639","doi":"10.3390/cancers13102407","title":"Histone Acetyltransferases and Stem Cell Identity","year":2021,"lang":"en","type":"review","venue":"Cancers","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Calgary","funders":"Alberta Children's Hospital Research Institute","keywords":"Stem cell; Biology; Histone; Cell biology; Induced pluripotent stem cell; Epigenetics; Cellular differentiation; Epigenetic regulation of neurogenesis; Gene knockdown; Gene; Genetics; Embryonic stem cell; Histone methyltransferase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004132712,0.0007159133,0.0007972681,0.001450658,0.0002399928,0.0007917684,0.000770382,0.000987321,0.003903479],"category_scores_gemma":[0.0004253669,0.0002483201,0.0002875682,0.001481262,0.0005164726,0.0009786945,0.0006021693,0.001493206,0.00300079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008259742,"about_ca_system_score_gemma":0.0008249112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008692419,"about_ca_topic_score_gemma":0.001583285,"domain_scores_codex":[0.9998817,0.00001678552,0.00001619915,0.00002609123,0.00004410407,0.00001502288],"domain_scores_gemma":[0.9998566,0.00005324574,0.00001860467,0.000006290887,0.0000455405,0.00001971363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007942972,0.00003685749,0.0001969073,0.006903353,0.00006000143,0.0001923117,0.00004077679,0.0003616851,0.002925592,0.008850249,0.0378066,0.9425464],"study_design_scores_gemma":[0.000007028498,0.00003979713,0.0005536449,0.0008459017,0.00003129805,0.0006473777,0.00002075654,0.0000417938,0.0005418982,0.002192696,0.9950695,0.000008395173],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009755326,0.9977672,0.0001243401,0.0002839732,0.0002443083,0.000002888332,0.00001906769,0.000006625521,0.001454095],"genre_scores_gemma":[0.0007735484,0.9974745,0.0001379908,0.0001990514,0.0001418056,0.000004923624,0.00003844131,0.000001329358,0.001228416],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003903479,"threshold_uncertainty_score":0.01305842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03465696435674875,"score_gpt":0.3617858967922059,"score_spread":0.3271289324354571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}