{"id":"W3161802642","doi":"10.1111/bph.15531","title":"Inhibition of inflammatory pain and cough by a novel charged sodium channel blocker","year":2021,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute of Neurological Disorders and Stroke; National Heart, Lung, and Blood Institute; Boston Biomedical Innovation Center; U.S. Department of Defense","keywords":"Nociceptor; TRPV1; Pharmacology; Inflammation; Cough reflex; Sensitization; Chemistry; Medicine; Lidocaine; Hyperalgesia; Nociception; Neurogenic inflammation; Anesthesia; Transient receptor potential channel; Airway; Immunology; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001826111,0.0003039365,0.0003259985,0.0001989434,0.00013914,0.0002121858,0.0004846273,0.0003593692,0.001527577],"category_scores_gemma":[0.0001167221,0.0001068304,0.0002827616,0.0001251085,0.0002085259,0.0002845616,0.0001992781,0.0005427359,0.0003542624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001925801,"about_ca_system_score_gemma":0.0002961897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002037863,"about_ca_topic_score_gemma":0.0004340537,"domain_scores_codex":[0.9999149,0.00001272115,0.00001168265,0.00001744568,0.00002208881,0.00002115428],"domain_scores_gemma":[0.9999303,0.00001655733,0.00002136571,0.000003872205,0.000008941777,0.00001898425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003188586,0.0001428691,0.0001743205,0.0001297391,0.00001041428,0.00004777579,0.00001370967,0.00007167456,0.9952377,0.00008170409,0.00004453992,0.003726678],"study_design_scores_gemma":[0.0002788504,0.004690429,0.002863156,0.000024145,0.00005737635,0.0006912826,0.00002883782,0.001481146,0.9877847,0.00004888415,0.002041114,0.00001004092],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888495,0.00462252,0.004380993,0.0001381805,0.00005906446,0.00008679048,0.0001162909,0.0001023328,0.001644467],"genre_scores_gemma":[0.9911616,0.002596799,0.004358603,0.0001266941,0.00003177182,0.00008770106,0.0001759348,0.00001354829,0.001447239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001527577,"threshold_uncertainty_score":0.005110264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0167938080630733,"score_gpt":0.2590007939709112,"score_spread":0.242206985907838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}