{"id":"W3161865957","doi":"10.1161/circ.142.suppl_3.12594","title":"Abstract 12594: Pharmacodynamic Effect of ARO-APOC3, an Investigational Hepatocyte-targeted RNA Interference Therapeutic Targeting Apolipoprotein C3, in Patients With Hypertriglyceridemia and Multifactorial Chylomicronemia","year":2020,"lang":"en","type":"article","venue":"Circulation","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Université de Montréal; Université du Québec à Chicoutimi","funders":"","keywords":"Medicine; Hypertriglyceridemia; Tolerability; Internal medicine; Adverse effect; Apolipoprotein B; Placebo; Pharmacology; Endocrinology; Gastroenterology; Triglyceride; Cholesterol; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002872657,0.0004363564,0.0005864053,0.0002027452,0.0001523834,0.0002909834,0.0002120901,0.0004264159,0.002291166],"category_scores_gemma":[0.0003951335,0.0001353601,0.0004490769,0.000171187,0.0002438984,0.0002142938,0.0001259905,0.0009476353,0.0004007576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003417012,"about_ca_system_score_gemma":0.0003316493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006109482,"about_ca_topic_score_gemma":0.0013419,"domain_scores_codex":[0.9998759,0.00005016856,0.000009950342,0.00002047838,0.00002024501,0.00002333097],"domain_scores_gemma":[0.9998511,0.00003316749,0.00004249249,0.000008888478,0.00001149158,0.00005287494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4831949,0.02624379,0.01658277,0.0004819047,0.001126952,0.0006182676,0.0001508955,0.001446606,0.250454,0.0001300694,0.003638586,0.2159311],"study_design_scores_gemma":[0.1650535,0.6008515,0.1656114,0.00004418935,0.001323806,0.001157381,0.00009918199,0.004320306,0.05497136,0.0001659262,0.006328546,0.00007297755],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970863,0.0009181302,0.000233014,0.0001708007,0.00002553761,0.0001615302,0.0003554442,0.00006374758,0.0009853123],"genre_scores_gemma":[0.9976827,0.0002720533,0.0004782963,0.0002304195,0.00003574806,0.0001016399,0.0004016606,0.000007176624,0.0007902339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002291166,"threshold_uncertainty_score":0.00766474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01241577109494494,"score_gpt":0.2441859063656102,"score_spread":0.2317701352706653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}