{"id":"W3161865957","doi":"10.1161/circ.142.suppl_3.12594","title":"Abstract 12594: Pharmacodynamic Effect of ARO-APOC3, an Investigational Hepatocyte-targeted RNA Interference Therapeutic Targeting Apolipoprotein C3, in Patients With Hypertriglyceridemia and Multifactorial Chylomicronemia","year":2020,"lang":"en","type":"article","venue":"Circulation","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Université de Montréal; Université du Québec à Chicoutimi","funders":"","keywords":"Medicine; Hypertriglyceridemia; Tolerability; Internal medicine; Adverse effect; Apolipoprotein B; Placebo; Pharmacology; Endocrinology; Gastroenterology; Triglyceride; Cholesterol; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001973405,0.0002084046,0.0003827094,0.0001091508,0.00004309847,0.00001595307,0.00006597467,0.0001109831,0.00004171458],"category_scores_gemma":[0.0002088013,0.0001551848,0.00004165688,0.0002175304,0.0000922887,0.0002952272,0.00001927003,0.0002395651,0.000003802281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006126032,"about_ca_system_score_gemma":0.0001011378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002346307,"about_ca_topic_score_gemma":0.000006784174,"domain_scores_codex":[0.9986981,0.0001010358,0.0003951659,0.0003411233,0.0002688176,0.0001957578],"domain_scores_gemma":[0.9993162,0.00007813167,0.0002111262,0.0001243495,0.00009036267,0.000179861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001521606,0.00006042988,0.7060237,0.0001857445,0.00003134189,8.741542e-7,0.0005074392,0.0003127913,0.2828295,0.000009152447,0.000003450057,0.008513954],"study_design_scores_gemma":[0.008590862,0.0002688736,0.9488747,0.00008436701,0.00008161406,5.932453e-7,0.00003027785,0.0156801,0.02616586,0.00003394575,0.00001559867,0.0001732685],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983458,0.0001610891,0.0002062077,0.0000949869,0.0001579419,0.0009493813,0.00001741941,0.00004115753,0.00002600622],"genre_scores_gemma":[0.9989141,0.000008129508,0.000262938,0.0001667679,0.000211268,0.00002222955,0.0003857357,0.00002820375,5.887015e-7],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2566637,"threshold_uncertainty_score":0.6328251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01241577109494494,"score_gpt":0.2441859063656102,"score_spread":0.2317701352706653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}