{"id":"W3161866536","doi":"10.3390/biom11050738","title":"Metabolomics-Guided Hypothesis Generation for Mechanisms of Intestinal Protection by Live Biotherapeutic Products","year":2021,"lang":"en","type":"article","venue":"Biomolecules","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Okanagan University College; University of British Columbia, Okanagan Campus; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; University of British Columbia; Crohn's and Colitis Canada; Michael Smith Health Research BC","keywords":"Lactobacillus reuteri; Bacteria; Oxidative stress; Inflammation; Colitis; Chemistry; Escherichia coli; Microbiology; Probiotic; Pharmacology; Biology; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000611084,0.0007198587,0.0005326361,0.0007067318,0.0002361142,0.0008086112,0.0005187339,0.0006644286,0.001738147],"category_scores_gemma":[0.0005475891,0.0002289101,0.0008573801,0.0003081832,0.0004439151,0.001082045,0.0003871693,0.0007278032,0.0003419472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005331765,"about_ca_system_score_gemma":0.0007255611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003706574,"about_ca_topic_score_gemma":0.0004665609,"domain_scores_codex":[0.9998682,0.00003033443,0.000007158799,0.00004134415,0.00003035538,0.00002265881],"domain_scores_gemma":[0.999811,0.00005831922,0.00005206189,0.00001544916,0.00004456921,0.00001860006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009319579,0.0002998184,0.005231533,0.0013633,0.0001984741,0.0007285727,0.0001217711,0.008688177,0.9387064,0.009365062,0.0005708593,0.03379407],"study_design_scores_gemma":[0.0001723416,0.002739394,0.01546611,0.0002153361,0.0003818196,0.0007120353,0.0004945034,0.1477783,0.7996119,0.02123717,0.01106051,0.0001305626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6679624,0.02604872,0.2858103,0.003578043,0.0004097388,0.0009716768,0.002803667,0.0009320033,0.01148355],"genre_scores_gemma":[0.9135262,0.01017121,0.07264397,0.0005375259,0.00008171539,0.000361165,0.00100448,0.00002780748,0.001645896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001738147,"threshold_uncertainty_score":0.005814731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04690393140468208,"score_gpt":0.2751043139117273,"score_spread":0.2282003825070452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}