{"id":"W3161872113","doi":"10.1142/s1088424621500656","title":"Fast, facile, base-free microwave-assisted metallation of bacteriochlorophylls and corresponding high yield synthesis of TOOKAD","year":2021,"lang":"en","type":"article","venue":"Journal of Porphyrins and Phthalocyanines","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canada Foundation for Innovation","keywords":"Bacteriochlorophyll; Chemistry; Photodynamic therapy; Chromophore; Photochemistry; Combinatorial chemistry; Corrole; Yield (engineering); Microwave; Nanotechnology; Organic chemistry; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009095102,0.0002688861,0.0008839928,0.0002783893,0.0001298222,0.00002354613,0.0002375152,0.0002799817,0.001624547],"category_scores_gemma":[0.0005088673,0.0002323557,0.0002187831,0.0002596478,0.0002737021,0.0002099666,0.0001584118,0.0004204927,0.000002033696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002382728,"about_ca_system_score_gemma":0.0001443446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000426249,"about_ca_topic_score_gemma":0.00001885099,"domain_scores_codex":[0.9977975,0.0004522284,0.001020678,0.0002411186,0.0002216632,0.0002667406],"domain_scores_gemma":[0.9963854,0.001646873,0.001074938,0.0001983905,0.0004794419,0.000214937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009657248,0.000329293,0.01807022,0.0002481818,0.0006829621,0.0002112636,0.0004147643,0.00005566079,0.9526869,0.0005249386,0.0007128665,0.0250972],"study_design_scores_gemma":[0.00157288,0.0004209041,0.09426125,0.0001726959,0.0009159548,0.001406166,0.0004647597,0.0001292677,0.89622,0.0003269293,0.003846259,0.0002628746],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942867,0.002921992,0.0001632602,0.0005018169,0.0008101957,0.000117173,0.000210499,0.00000727943,0.0009810643],"genre_scores_gemma":[0.9957959,0.001779866,0.001600491,0.0001561493,0.0002400682,0.000004023407,0.000006139258,0.00002295032,0.0003943849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07619104,"threshold_uncertainty_score":0.9992881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07898516481058993,"score_gpt":0.3495968764026564,"score_spread":0.2706117115920665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}