{"id":"W3161920248","doi":"10.1016/j.molimm.2021.04.027","title":"Tatibody, a recombinant antibody with higher internalization potency","year":2021,"lang":"en","type":"article","venue":"Molecular Immunology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences; Shiraz University of Medical Sciences","keywords":"Internalization; Pertuzumab; Recombinant DNA; Antibody; Antibody-dependent cell-mediated cytotoxicity; Potency; Chemistry; Receptor; Molecular biology; Biochemistry; Monoclonal antibody; Biology; In vitro; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005610572,0.001029233,0.0006527021,0.0006286348,0.0003892653,0.0009430606,0.000872963,0.001057381,0.004017194],"category_scores_gemma":[0.0004042009,0.0003529931,0.000783932,0.0004089957,0.0003056851,0.000524099,0.0004712301,0.002286554,0.001873222],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006245358,"about_ca_system_score_gemma":0.0004875537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007724731,"about_ca_topic_score_gemma":0.000548917,"domain_scores_codex":[0.9993479,0.0001239545,0.00005484639,0.0001710967,0.0001118559,0.0001903671],"domain_scores_gemma":[0.999783,0.00006554216,0.00002359693,0.00003394127,0.00005115691,0.00004286967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001748774,0.00005622081,0.00009910109,0.000103008,0.00002766233,0.00007462046,0.00002189753,0.00007748001,0.9956748,0.0003569591,0.0003164884,0.003016941],"study_design_scores_gemma":[0.0001139732,0.0004898424,0.001067706,0.00001807497,0.0001227591,0.00129206,0.00001982558,0.00120203,0.9843911,0.0001096373,0.01115849,0.00001452999],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9094331,0.01979954,0.05297959,0.0009869753,0.0007368757,0.0002666347,0.001077951,0.001521014,0.01319833],"genre_scores_gemma":[0.9556599,0.003951445,0.02466484,0.0006783843,0.0002328031,0.0001677358,0.003541972,0.0002123846,0.01089054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004017194,"threshold_uncertainty_score":0.01343888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01114971471005013,"score_gpt":0.3076853030154587,"score_spread":0.2965355883054086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}