{"id":"W3161920248","doi":"10.1016/j.molimm.2021.04.027","title":"Tatibody, a recombinant antibody with higher internalization potency","year":2021,"lang":"en","type":"article","venue":"Molecular Immunology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences; Shiraz University of Medical Sciences","keywords":"Internalization; Pertuzumab; Recombinant DNA; Antibody; Antibody-dependent cell-mediated cytotoxicity; Potency; Chemistry; Receptor; Molecular biology; Biochemistry; Monoclonal antibody; Biology; In vitro; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00006936046,0.0001540669,0.0002876075,0.0001016334,0.00006662648,0.00002057597,0.0001051358,0.0001060168,0.001107056],"category_scores_gemma":[0.00004409845,0.0001159025,0.000092702,0.0002932542,0.0001473911,0.00004110024,0.0001168853,0.0002723896,0.0001600478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003941017,"about_ca_system_score_gemma":0.0001773271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001871099,"about_ca_topic_score_gemma":0.000008429522,"domain_scores_codex":[0.9987804,0.0001204212,0.0002062817,0.0003122984,0.0002438776,0.0003366815],"domain_scores_gemma":[0.9992291,0.00002603713,0.00005232255,0.0003253991,0.0002883318,0.00007885991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006071554,0.0002198341,0.008248097,0.00006794316,0.000447754,0.006919462,0.00008043654,0.000004820582,0.9623614,0.01544514,0.000318604,0.005279373],"study_design_scores_gemma":[0.005783372,0.00323491,0.1653098,0.0005672831,0.0002458855,0.007898802,0.0001598413,0.0003539715,0.5908012,0.002476125,0.222497,0.0006718509],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9658119,0.004577843,0.007267916,0.00741328,0.000345747,0.0001976211,0.000004113001,0.00005696858,0.01432459],"genre_scores_gemma":[0.9585623,0.000653189,0.002121346,0.00158276,0.00005276893,0.00001916439,0.0003702094,0.00004009177,0.03659824],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3715602,"threshold_uncertainty_score":0.999806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01114971471005013,"score_gpt":0.3076853030154587,"score_spread":0.2965355883054086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}