{"id":"W3161922739","doi":"10.15252/embr.202052173","title":"OCRL regulates lysosome positioning and mTORC1 activity through SSX2IP-mediated microtubule anchoring","year":2021,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Eye Institute; National Institutes of Health; U.S. Department of Veterans Affairs; E. Matilda Ziegler Foundation for the Blind; Children's Health Research Institute; Ögonfonden; Ralph W. and Grace M. Showalter Research Trust Fund; BrightFocus Foundation; American Glaucoma Society; Glaucoma Research Foundation; Lowe Syndrome Association; Knights Templar Eye Foundation; Foundation for the National Institutes of Health","keywords":"Lysosome; mTORC1; Cell biology; Anchoring; Microtubule; Biology; Biochemistry; Signal transduction; Psychology; PI3K/AKT/mTOR pathway; Enzyme; Cognitive science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001204259,0.0001351404,0.0001517398,0.00001732151,0.0001244275,0.00003926027,0.00003032321,0.0001470161,0.00004722324],"category_scores_gemma":[0.00003891355,0.00014627,0.00007611121,0.00008464582,0.00004727634,0.00001275822,0.0000466772,0.00008777749,0.000002099001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001559164,"about_ca_system_score_gemma":0.00006268977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004375829,"about_ca_topic_score_gemma":0.00004147814,"domain_scores_codex":[0.9990227,0.0000305634,0.000202335,0.0004353558,0.0001110527,0.0001980108],"domain_scores_gemma":[0.9994327,0.000006815141,0.0001042922,0.0003079782,0.0000830258,0.00006515058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001815456,0.00003492226,0.01367358,0.0000250528,0.00004152452,0.000408509,0.00008154961,0.00001066473,0.9853039,0.00001911591,0.0000964706,0.0002865196],"study_design_scores_gemma":[0.0001999876,0.00004446413,0.02261296,0.00003424576,0.00002894067,0.000571365,0.00004393713,0.00001649957,0.9471377,0.0002196535,0.02888556,0.000204644],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992837,0.002320426,0.002567264,0.0001097462,0.0002036764,0.00009255892,0.000005958384,0.00002562232,0.001837715],"genre_scores_gemma":[0.995894,0.0003376665,0.0004739625,0.00007972446,0.0002544415,0.000008279713,0.00189136,0.00002049194,0.001040065],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0381662,"threshold_uncertainty_score":0.5964718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007558435521094435,"score_gpt":0.2215692813630856,"score_spread":0.2140108458419912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}