{"id":"W3161922739","doi":"10.15252/embr.202052173","title":"OCRL regulates lysosome positioning and mTORC1 activity through SSX2IP-mediated microtubule anchoring","year":2021,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Eye Institute; National Institutes of Health; U.S. Department of Veterans Affairs; E. Matilda Ziegler Foundation for the Blind; Children's Health Research Institute; Ögonfonden; Ralph W. and Grace M. Showalter Research Trust Fund; BrightFocus Foundation; American Glaucoma Society; Glaucoma Research Foundation; Lowe Syndrome Association; Knights Templar Eye Foundation; Foundation for the National Institutes of Health","keywords":"Lysosome; mTORC1; Cell biology; Anchoring; Microtubule; Biology; Biochemistry; Signal transduction; Psychology; PI3K/AKT/mTOR pathway; Enzyme; Cognitive science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002134394,0.0005081366,0.0003341524,0.0004155136,0.0004091304,0.001538613,0.0004684256,0.0004888498,0.002980336],"category_scores_gemma":[0.0003072713,0.0002855993,0.000399269,0.0003007035,0.000581018,0.0006326836,0.001056271,0.0006958612,0.001367763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001385265,"about_ca_system_score_gemma":0.0005349529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002166355,"about_ca_topic_score_gemma":0.003875058,"domain_scores_codex":[0.9996853,0.00002100508,0.00002930622,0.00009039174,0.00007219811,0.0001017548],"domain_scores_gemma":[0.9996914,0.00002783688,0.0001238528,0.00003364859,0.00004087068,0.00008250366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000456041,0.00003062487,0.0009264444,0.00005229441,0.000009168319,0.00013959,0.00002463184,0.0000952257,0.9951212,0.0004236403,0.0002863625,0.002434872],"study_design_scores_gemma":[0.00005920278,0.0000641432,0.02192516,0.00001520141,0.00002463182,0.0001561536,0.0001036044,0.001290286,0.9706299,0.0001478937,0.005568396,0.00001536361],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848932,0.004017475,0.002937825,0.000580409,0.0001468197,0.00002565589,0.001168837,0.0003418682,0.005887774],"genre_scores_gemma":[0.991199,0.0007307112,0.0009635591,0.0001307898,0.00002288178,0.00002478167,0.0009411077,0.0001290195,0.005858165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002980336,"threshold_uncertainty_score":0.01005089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007558435521094435,"score_gpt":0.2215692813630856,"score_spread":0.2140108458419912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}