{"id":"W3161927456","doi":"10.3389/fmolb.2021.659058","title":"Phenotypic and Multi-Omics Characterization of Escherichia coli K-12 Adapted to Chlorhexidine Identifies the Role of MlaA and Other Cell Envelope Alterations Regulated by Stress Inducible Pathways in CHX Resistance","year":2021,"lang":"en","type":"article","venue":"Frontiers in Molecular Biosciences","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Public Health Agency; Public Health Agency of Canada","keywords":"Efflux; Biology; Transcriptome; Escherichia coli; Gene; Cell biology; Gene expression; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002187675,0.0001245001,0.0001911556,0.00007629702,0.0000553291,0.00004949431,0.0001927197,0.0001017587,0.000001990345],"category_scores_gemma":[0.0000921846,0.0001112415,0.00002087712,0.0003814302,0.0002777321,0.0000157186,0.0001055195,0.00005808441,7.675843e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001117678,"about_ca_system_score_gemma":0.00008364565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003178731,"about_ca_topic_score_gemma":0.0002029399,"domain_scores_codex":[0.998903,0.0001098043,0.0003092721,0.0003771464,0.0001332011,0.0001675542],"domain_scores_gemma":[0.9994701,0.000007376013,0.0001567255,0.0002557648,0.00007038429,0.00003963781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004545582,0.00006460337,0.04199354,0.00002759618,0.000009388225,0.000001167482,0.0003777019,0.00002668095,0.9572196,0.0000581496,0.0000263596,0.0001497593],"study_design_scores_gemma":[0.0002611409,0.00003573672,0.0545669,0.00005808017,0.000006812507,4.00488e-7,0.001102971,0.0004351189,0.9428442,0.00006566917,0.0005058347,0.0001172046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899065,0.001963445,0.007516514,0.00008998952,0.0001193069,0.0002313633,0.0001148315,0.000002765899,0.00005529275],"genre_scores_gemma":[0.9893968,0.0003408553,0.009939766,0.00008281101,0.000007632428,0.00000835693,0.00006268357,0.00001153028,0.0001496315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01437547,"threshold_uncertainty_score":0.4536299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007095374232941739,"score_gpt":0.2075956999525741,"score_spread":0.2005003257196324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}