{"id":"W3161987942","doi":"10.1096/fj.202100264r","title":"Membrane morphology determines diacylglycerol kinase α substrate acyl chain specificity","year":2021,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Hamilton Health Sciences; Health Sciences Centre; McMaster University Medical Centre","funders":"Japan Society for the Promotion of Science; Canadian Natural Resources Limited","keywords":"Diacylglycerol kinase; Phosphatidic acid; Membrane; Biochemistry; Biological membrane; Biophysics; Chemistry; Kinase; Protein kinase C; Biology; Cell biology; Phospholipid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001040424,0.0002301777,0.0001531056,0.0001325601,0.00009244132,0.0004646976,0.0001314873,0.0002422753,0.0005349957],"category_scores_gemma":[0.0002628386,0.0001699824,0.0001633675,0.0001462122,0.0001870449,0.0003609649,0.0001849712,0.0002718012,0.0004039609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002700383,"about_ca_system_score_gemma":0.00009872516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002650486,"about_ca_topic_score_gemma":0.0002423028,"domain_scores_codex":[0.9998662,0.00002328884,0.00001315342,0.00004280264,0.00003217013,0.0000223102],"domain_scores_gemma":[0.999878,0.00002177772,0.00004686431,0.00001608854,0.00002001015,0.00001724682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005686153,0.00000251672,0.0004554787,0.00001053213,0.000002097461,0.00002718071,0.000009008184,0.00003329555,0.9988709,0.00005742014,0.00000497556,0.0004695651],"study_design_scores_gemma":[0.000004445106,0.00005048981,0.0118474,0.000004510742,0.000008996795,0.0003314591,0.00003732797,0.0006769582,0.9858596,0.0001051315,0.001067571,0.000006069792],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947742,0.001188642,0.003080989,0.00005354236,0.00001121825,0.00001031961,0.0001412886,0.00001991159,0.0007199888],"genre_scores_gemma":[0.9978203,0.0007173186,0.0007798802,0.0000185608,0.000002406493,0.000005691317,0.0001512969,0.000006504085,0.000498136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005349957,"threshold_uncertainty_score":0.001959264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02197232100033168,"score_gpt":0.240338578175728,"score_spread":0.2183662571753963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}