{"id":"W3162005964","doi":"10.1159/000515740","title":"Intracellular and Extracellular Lipopolysaccharide Signaling in Sepsis: Avenues for Novel Therapeutic Strategies","year":2021,"lang":"en","type":"review","venue":"Journal of Innate Immunity","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":142,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto Public Health","funders":"Canadian Institutes of Health Research; National Natural Science Foundation of China","keywords":"Pyroptosis; Cell biology; Inflammasome; Pyrin domain; Caspase; TLR4; Biology; Extracellular; Inflammation; Intracellular; Lipopolysaccharide; Signal transduction; Immunology; Apoptosis; Programmed cell death; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001094886,0.0008705855,0.001645124,0.0008526398,0.0003174452,0.001830592,0.001113485,0.001611282,0.006830602],"category_scores_gemma":[0.0005969008,0.0002455431,0.001047179,0.0006102721,0.000967378,0.002233269,0.001044766,0.005329088,0.001920766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000561941,"about_ca_system_score_gemma":0.001085459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002831638,"about_ca_topic_score_gemma":0.0007773112,"domain_scores_codex":[0.999721,0.00008148464,0.00002300272,0.00003744658,0.00005264446,0.00008435144],"domain_scores_gemma":[0.9996314,0.0000910171,0.00005396516,0.00002491423,0.00009878429,0.00009988269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003221847,0.002690352,0.0008172585,0.01144909,0.0004621228,0.001232382,0.0003322897,0.001874107,0.04737805,0.03580628,0.06444269,0.8302937],"study_design_scores_gemma":[0.001939115,0.006688979,0.003235302,0.006728258,0.000749159,0.002257232,0.0005735347,0.003373837,0.01246598,0.04104109,0.920766,0.0001815804],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006020927,0.9705889,0.00504035,0.01113079,0.001948595,0.0001223972,0.0002090349,0.0001613427,0.004777587],"genre_scores_gemma":[0.03313621,0.9487432,0.005453964,0.005260372,0.00305879,0.0002977478,0.0005401543,0.00003668805,0.003472826],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006830602,"threshold_uncertainty_score":0.02285063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03574582573761129,"score_gpt":0.3194818008375546,"score_spread":0.2837359750999433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}