{"id":"W3162008887","doi":"10.3390/ph14050444","title":"Hexarelin Modulation of MAPK and PI3K/Akt Pathways in Neuro-2A Cells Inhibits Hydrogen Peroxide—Induced Apoptotic Toxicity","year":2021,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakehead University","funders":"","keywords":"Neuroprotection; Viability assay; Protein kinase B; Apoptosis; Chemistry; PI3K/AKT/mTOR pathway; Caspase 3; MAPK/ERK pathway; Pharmacology; Western blot; Cell biology; Programmed cell death; Signal transduction; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002294116,0.00014777,0.0001941892,0.00005034938,0.00003816917,0.0000147275,0.00006473845,0.0001563271,0.00004663851],"category_scores_gemma":[0.00007329993,0.0001499192,0.0000662139,0.0001356034,0.00003520404,0.000007404053,0.0001224174,0.0001060242,0.000004458776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001301396,"about_ca_system_score_gemma":0.00004968486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006165005,"about_ca_topic_score_gemma":0.00001007005,"domain_scores_codex":[0.9988031,0.0001219469,0.0003233197,0.0003801864,0.0001507566,0.0002206937],"domain_scores_gemma":[0.9994966,0.0000297758,0.00007537506,0.0002055295,0.00008368249,0.0001090241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000380374,0.0001133112,0.0002714457,0.00005369253,0.00001497771,0.000007650127,0.00005429107,0.0005407017,0.9936369,0.0001696875,0.00001682622,0.005082447],"study_design_scores_gemma":[0.0007515082,0.0000797526,0.002076523,0.00002122997,0.00002269469,0.00001392138,0.00003040556,0.007263977,0.9886264,0.0003492252,0.0006098054,0.0001546148],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997858,0.0007512821,0.0007317516,0.0001530927,0.0001090489,0.0002159243,0.00001511931,0.000009429813,0.0001563617],"genre_scores_gemma":[0.9985693,0.0004955363,0.0004016599,0.0002871899,0.0000811005,0.000008518257,0.00006481797,0.00002018415,0.000071722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006723275,"threshold_uncertainty_score":0.6113528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03463913094464161,"score_gpt":0.287806555288926,"score_spread":0.2531674243442844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}