{"id":"W3162028161","doi":"10.1021/acs.jmedchem.1c00146","title":"Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders","year":2021,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Structural Genomics Consortium; University of Toronto","funders":"Deutsche Krebshilfe; Bundesministerium für Bildung und Forschung; H2020 European Research Council; Deutsche Forschungsgemeinschaft","keywords":"Chemistry; Methyltransferase; Histone; Linker; Methylation; Epigenetics; Protein biosynthesis; Acetylation; Computational biology; Gene; Cell biology; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003029581,0.0003933845,0.0002852396,0.0002812092,0.0001136839,0.0002543785,0.0002953367,0.0002680999,0.0008103113],"category_scores_gemma":[0.0001978745,0.0001302343,0.0003082434,0.0001953963,0.0001334745,0.0002666565,0.0001966724,0.000314987,0.0002927528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002597398,"about_ca_system_score_gemma":0.0002106767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001916276,"about_ca_topic_score_gemma":0.0004219848,"domain_scores_codex":[0.9998548,0.00002294594,0.00001647667,0.00003031213,0.00004207295,0.00003336421],"domain_scores_gemma":[0.9998924,0.000009368349,0.00004120231,0.0000104727,0.00001947971,0.00002708532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002757756,0.0002597406,0.000206405,0.0003847319,0.0000410522,0.0002574029,0.00007628288,0.002640001,0.971786,0.001190657,0.000293495,0.02258839],"study_design_scores_gemma":[0.0001222336,0.004439782,0.001191722,0.00002921815,0.00005254359,0.0004075533,0.00003513297,0.00139021,0.9818816,0.0001660357,0.01025681,0.00002718304],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9621375,0.008787039,0.02041135,0.0002357834,0.00007258293,0.0004209501,0.0008904568,0.0002435411,0.00680093],"genre_scores_gemma":[0.9765232,0.006360957,0.01270657,0.0001350897,0.00002115693,0.0001054307,0.0005975856,0.00002377123,0.00352614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008103113,"threshold_uncertainty_score":0.002710819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02507266520906692,"score_gpt":0.2816529760304904,"score_spread":0.2565803108214235,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}