{"id":"W3162028161","doi":"10.1021/acs.jmedchem.1c00146","title":"Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders","year":2021,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Structural Genomics Consortium; University of Toronto","funders":"Deutsche Krebshilfe; Bundesministerium für Bildung und Forschung; H2020 European Research Council; Deutsche Forschungsgemeinschaft","keywords":"Chemistry; Methyltransferase; Histone; Linker; Methylation; Epigenetics; Protein biosynthesis; Acetylation; Computational biology; Gene; Cell biology; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001203268,0.0001030088,0.0001993708,0.00002519525,0.00002944358,0.000007761138,0.00007913909,0.0001525764,0.00005695444],"category_scores_gemma":[0.000899695,0.00009532754,0.00007045818,0.00007611654,0.00007445566,0.000006044883,0.00002579613,0.0001414796,1.5454e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005931068,"about_ca_system_score_gemma":0.0006472287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002778624,"about_ca_topic_score_gemma":0.000001332076,"domain_scores_codex":[0.9987519,0.0001086594,0.0003830797,0.0001493082,0.0004949237,0.0001120983],"domain_scores_gemma":[0.9986832,0.00003225402,0.0004150763,0.0001494637,0.0006345733,0.00008540406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001995646,0.00002667082,0.0002266552,0.00007433644,0.000118811,0.000009189914,0.00005668449,0.0006115594,0.9820706,7.033817e-7,0.0001720194,0.01643325],"study_design_scores_gemma":[0.0009695262,0.0001505257,0.0006155796,0.0003270223,0.000242497,0.0005359715,0.0004944066,0.0004454952,0.995751,0.00006696746,0.000314426,0.00008663417],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859521,0.01085342,0.002370956,0.0003774805,0.00006557153,0.00008590079,0.000001390627,0.000001737409,0.0002913817],"genre_scores_gemma":[0.9979109,0.00022524,0.001374123,0.00001840328,0.0003712531,0.000005932163,0.000008128766,0.00001167098,0.000074308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01634661,"threshold_uncertainty_score":0.3887344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02507266520906692,"score_gpt":0.2816529760304904,"score_spread":0.2565803108214235,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}