{"id":"W3162077173","doi":"10.1111/cts.13042","title":"Effect of difelikefalin, a selective kappa opioid receptor agonist, on respiratory depression<b>:</b>A randomized, double‐blind, placebo‐controlled trial","year":2021,"lang":"en","type":"article","venue":"Clinical and Translational Science","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Altasciences (Canada); University of Toronto","funders":"","keywords":"Placebo; Medicine; Crossover study; Anesthesia; Agonist; Randomized controlled trial; Opioid; κ-opioid receptor; Respiratory system; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001041102,0.0009635519,0.002643705,0.0003277477,0.000427841,0.0006695291,0.0006487516,0.001770501,0.005924078],"category_scores_gemma":[0.001002741,0.0004530188,0.001023751,0.0002769122,0.0005771473,0.0005194187,0.0002091705,0.001565211,0.0007598273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004057397,"about_ca_system_score_gemma":0.0007425906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007367356,"about_ca_topic_score_gemma":0.001317217,"domain_scores_codex":[0.9995695,0.0002051734,0.0000521107,0.00007817715,0.00003706404,0.00005799536],"domain_scores_gemma":[0.999467,0.0001516422,0.0001212259,0.00002798275,0.000049194,0.0001830664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9750973,0.004043915,0.0002412415,0.001237353,0.0004902444,0.00003004549,0.00001598003,0.00007538337,0.00445292,0.00005381589,0.0006298234,0.01363199],"study_design_scores_gemma":[0.9338228,0.06333199,0.001448165,0.00004433714,0.0002662581,0.00002125275,0.00000811643,0.0001771709,0.0004347846,0.00003671894,0.0004005381,0.000007728859],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735602,0.01224979,0.0007946818,0.000814628,0.0009576814,0.006868948,0.001562187,0.0001999754,0.002991922],"genre_scores_gemma":[0.9818143,0.005318029,0.001486797,0.001533983,0.0006279228,0.005784205,0.0008086545,0.00002260312,0.002603412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005924078,"threshold_uncertainty_score":0.01981801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0581552010232877,"score_gpt":0.3740919280211172,"score_spread":0.3159367269978295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}