{"id":"W3162077173","doi":"10.1111/cts.13042","title":"Effect of difelikefalin, a selective kappa opioid receptor agonist, on respiratory depression<b>:</b>A randomized, double‐blind, placebo‐controlled trial","year":2021,"lang":"en","type":"article","venue":"Clinical and Translational Science","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Altasciences (Canada); University of Toronto","funders":"","keywords":"Placebo; Medicine; Crossover study; Anesthesia; Agonist; Randomized controlled trial; Opioid; κ-opioid receptor; Respiratory system; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002838114,0.0002019744,0.0008956459,0.00008314705,0.000374128,0.00005903467,0.0002910433,0.0001009393,0.00006812729],"category_scores_gemma":[0.00388926,0.0001302897,0.000381035,0.0005213739,0.002389924,0.0001896274,0.00007227817,0.0003607113,0.00002428566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005640412,"about_ca_system_score_gemma":0.0003554595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003571466,"about_ca_topic_score_gemma":0.000001680325,"domain_scores_codex":[0.9959595,0.001385609,0.0008571713,0.0009251446,0.0005785532,0.0002939847],"domain_scores_gemma":[0.9896452,0.009546514,0.000252368,0.0002066161,0.0001422359,0.0002070902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8342025,0.0002280748,0.0001449826,0.00001315587,0.00001113343,0.000006891666,0.00002892254,0.00004039115,0.1586957,0.003988681,0.00002966607,0.00260995],"study_design_scores_gemma":[0.8252243,0.001520177,0.0003009382,0.00003760582,0.00004731862,0.000003871999,0.000002001762,0.0003087145,0.1703811,0.001514514,0.0005139408,0.0001455118],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936103,0.0001274406,0.00004064227,0.0001793778,0.0006691543,0.001622769,0.0000158567,0.00002796635,0.003706458],"genre_scores_gemma":[0.9985497,0.00009475625,0.00007262178,0.0006737132,0.0003352867,0.000132639,0.000002081006,0.000010334,0.0001288468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01168541,"threshold_uncertainty_score":0.8805774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0581552010232877,"score_gpt":0.3740919280211172,"score_spread":0.3159367269978295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}