{"id":"W3162079026","doi":"10.1111/acel.13373","title":"Smc5/6 in the rDNA modulates lifespan independently of Fob1","year":2021,"lang":"en","type":"article","venue":"Aging Cell","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Biology; Nucleolus; Genetics; Ribosomal DNA; Saccharomyces cerevisiae; Homologous recombination; Gene silencing; DNA; DNA repair; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001939143,0.00007360429,0.00008043031,0.00002043968,0.00001942602,0.00001207438,0.0001824873,0.00006793412,0.00001666781],"category_scores_gemma":[0.00003043019,0.00006163078,0.00005624979,0.00008465092,0.00001800575,0.000001762148,0.0001014555,0.0000737678,0.000006233326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004538796,"about_ca_system_score_gemma":0.00004378393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003356038,"about_ca_topic_score_gemma":0.00005060575,"domain_scores_codex":[0.9993566,0.00007499054,0.0001244311,0.0001937642,0.000109334,0.0001408322],"domain_scores_gemma":[0.9995422,0.00001386886,0.00004325176,0.0003466276,0.00003408355,0.00001995047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000004136655,0.00006390811,0.004644896,0.00001953824,0.000009572364,0.00002071963,0.0002214166,0.00007217068,0.9940796,0.00009669655,0.0002405467,0.0005267815],"study_design_scores_gemma":[0.0002407735,0.0000389937,0.002069968,0.00001039338,0.000007561285,0.00001129161,0.0003554181,0.00009692081,0.9935844,0.0003519763,0.003156828,0.00007546347],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945151,0.0007423994,0.0002064984,0.0001659228,0.00008664634,0.00006157469,0.000002819514,0.00000556265,0.004213491],"genre_scores_gemma":[0.9980231,0.00005020943,0.0005147689,0.0003435699,0.00005391299,0.00000465811,0.00002817198,0.00001125355,0.0009703561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003508014,"threshold_uncertainty_score":0.251323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007289378129460031,"score_gpt":0.2263512736895672,"score_spread":0.2190618955601072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}