{"id":"W3162084837","doi":"10.1038/s41588-021-00856-5","title":"Two competing mechanisms of DNMT3A recruitment regulate the dynamics of de novo DNA methylation at PRC1-targeted CpG islands","year":2021,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":107,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill Genome Centre; McGill University","funders":"National Institute of General Medical Sciences; McGill University; Damon Runyon Cancer Research Foundation; American Association for Cancer Research; St. Jude Children's Research Hospital; National Cancer Institute; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Biology; DNA methylation; EZH2; Histone; Histone H3; Epigenetics; CpG site; Histone methylation; Genetics; Epigenomics; Methylation; Cell biology; Cancer epigenetics; Histone methyltransferase; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001864318,0.0006152062,0.001372485,0.000751606,0.001035243,0.003162951,0.00157128,0.001424626,0.004848156],"category_scores_gemma":[0.00311749,0.00124905,0.001056554,0.0004490802,0.001162352,0.003205962,0.00220099,0.0021238,0.001873924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002613014,"about_ca_system_score_gemma":0.001292092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002265132,"about_ca_topic_score_gemma":0.004638835,"domain_scores_codex":[0.9983007,0.0001206289,0.0001392668,0.0005959269,0.0004223039,0.0004211717],"domain_scores_gemma":[0.9982839,0.0005970452,0.000238921,0.0002299338,0.0002565875,0.0003935364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008588413,0.00007210191,0.003924057,0.0003159302,0.00006622673,0.0001259023,0.0003020201,0.000744353,0.9682593,0.01446486,0.0005646079,0.01030174],"study_design_scores_gemma":[0.0001331862,0.000116633,0.02000467,0.00002584512,0.00004655245,0.0003090235,0.0001709266,0.0175035,0.9554597,0.002200845,0.003942015,0.00008714986],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9188114,0.008297397,0.05892745,0.001571429,0.0004482703,0.0002108856,0.001173294,0.0009337972,0.009625924],"genre_scores_gemma":[0.9775973,0.001032731,0.01361056,0.0001786736,0.00005101959,0.0001860957,0.0005744128,0.0001932719,0.006575964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004848156,"threshold_uncertainty_score":0.01895881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01401267040529265,"score_gpt":0.286619003427234,"score_spread":0.2726063330219413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}