{"id":"W3162222593","doi":"10.1136/annrheumdis-2020-219014","title":"Efficacy and safety of tildrakizumab in patients with active psoriatic arthritis: results of a randomised, double-blind, placebo-controlled, multiple-dose, 52-week phase IIb study","year":2021,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Sun Pharma","keywords":"Medicine; Placebo; Internal medicine; Psoriatic arthritis; Adverse effect; Psoriasis; Clinical endpoint; Psoriasis Area and Severity Index; Enthesitis; Arthritis; Randomized controlled trial; Dermatology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005753868,0.001666692,0.004061387,0.0004331766,0.0006148428,0.001181137,0.0009926836,0.002764651,0.005426753],"category_scores_gemma":[0.002545771,0.0009586799,0.002416059,0.0005167449,0.0009798952,0.0009855147,0.0003164918,0.002595915,0.001300927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007221107,"about_ca_system_score_gemma":0.001214768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000637484,"about_ca_topic_score_gemma":0.001078678,"domain_scores_codex":[0.9980087,0.00116014,0.000209829,0.000238312,0.0001994319,0.0001836455],"domain_scores_gemma":[0.9980686,0.0003973449,0.0005598051,0.0001607209,0.0001912646,0.0006222017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9431109,0.01355991,0.002160435,0.0009218603,0.001438962,0.00006664888,0.0001231418,0.0001951177,0.009832161,0.00004976256,0.0007867618,0.0277544],"study_design_scores_gemma":[0.9124462,0.08111285,0.004739051,0.00003070765,0.0005861993,0.00004539919,0.00001171275,0.000128058,0.0003753057,0.00003314242,0.0004804602,0.0000110189],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760666,0.01295862,0.0009614936,0.0008309931,0.0003517203,0.005481793,0.001038887,0.0001333336,0.002176506],"genre_scores_gemma":[0.9821823,0.004996309,0.002067556,0.001860318,0.0008057062,0.004625535,0.001470106,0.00003457402,0.001957701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005753868,"threshold_uncertainty_score":0.03042978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03058301587270064,"score_gpt":0.3090432301438472,"score_spread":0.2784602142711465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}