{"id":"W3162246240","doi":"10.1161/circ.142.suppl_3.13575","title":"Abstract 13575: Lack of Both Mitochondrial Proteins Sirt3 and Ucp2 in Mice Recapitulates Many Critical Features of Human Pulmonary Arterial Hypertension (PAH), Including Inflammatory Plexogenic Lesions, Supporting the Metabolic Theory of PAH","year":2020,"lang":"en","type":"article","venue":"Circulation","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"SIRT3; Medicine; Insulin resistance; Internal medicine; Endocrinology; Mitochondrion; Diabetes mellitus; Biology; Sirtuin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002998084,0.001478782,0.0007176155,0.001409615,0.0006324889,0.0006576166,0.0007667299,0.00130283,0.01142129],"category_scores_gemma":[0.0001909777,0.0005199463,0.0007604083,0.0005730128,0.001601512,0.0005662987,0.0006392505,0.001994102,0.002398098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007357274,"about_ca_system_score_gemma":0.0005160445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001935176,"about_ca_topic_score_gemma":0.003786459,"domain_scores_codex":[0.9993426,0.000075918,0.00009457785,0.0001943929,0.00019529,0.00009725214],"domain_scores_gemma":[0.9994397,0.00003522799,0.000201502,0.00004923203,0.00002661193,0.0002477849],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006201115,0.0001649747,0.0005150627,0.00007930057,0.00004096618,0.0003749906,0.00004374756,0.000107423,0.9959441,0.0004306928,0.0004196781,0.00125888],"study_design_scores_gemma":[0.0006814809,0.001740034,0.02668327,0.00009246107,0.000216316,0.005842252,0.0002049823,0.002047159,0.9382655,0.0004748587,0.02368916,0.00006242581],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9623926,0.001806095,0.01349992,0.001356211,0.0005644127,0.0002983151,0.01318409,0.001269399,0.005628912],"genre_scores_gemma":[0.9492667,0.001316912,0.01247784,0.0007879958,0.0001454101,0.000631943,0.0074047,0.0007203717,0.02724819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01142129,"threshold_uncertainty_score":0.03820801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07703824312002616,"score_gpt":0.3328281912615701,"score_spread":0.2557899481415439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}