{"id":"W3162249549","doi":"10.1002/hbm.25531","title":"Causal structural covariance network revealing atrophy progression in Alzheimer's disease continuum","year":2021,"lang":"en","type":"article","venue":"Human Brain Mapping","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; Fundamental Research Funds for the Central Universities; National Institutes of Health; H. Lundbeck A/S; National Natural Science Foundation of China; Eisai; Servier; Government of Jiangsu Province; IXICO; Pfizer; Biogen; BioClinica; Jiangsu Commission of Health; Northern California Institute for Research and Education; University of Southern California; Nanjing University; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; F. Hoffmann-La Roche; Alzheimer's Drug Discovery Foundation; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Covariance; Atrophy; Disease; Neuroscience; Psychology; Medicine; Pathology; Mathematics; Statistics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004751368,0.0001702239,0.0002848267,0.00009856798,0.0002746189,0.00008370312,0.00008841817,0.00005589886,0.0005239579],"category_scores_gemma":[0.0002173261,0.0001627746,0.00009548177,0.0003985283,0.00008836641,0.0001104714,0.0001433546,0.000334765,0.00002022102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005904593,"about_ca_system_score_gemma":0.0001696635,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001230695,"about_ca_topic_score_gemma":0.00002980563,"domain_scores_codex":[0.9980136,0.0002276119,0.0003330264,0.0004329795,0.0004167611,0.0005760782],"domain_scores_gemma":[0.9991755,0.00007840722,0.00008143042,0.0002593409,0.0001619394,0.0002433678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003519186,0.0001627689,0.9091362,0.0002934519,0.000245213,0.004959072,0.0004993918,0.00004651048,0.06161878,0.002816289,0.008174252,0.01169609],"study_design_scores_gemma":[0.002140754,0.00009274316,0.9899173,0.001408566,0.00006634619,0.00002910454,0.0001524588,0.0007300087,0.0003159622,0.001680457,0.003268373,0.0001979023],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905015,0.002796685,0.00094165,0.002794009,0.0002028157,0.0006895108,0.000004938838,0.00007300744,0.001995861],"genre_scores_gemma":[0.9952474,0.00001209318,0.001625555,0.001208035,0.0006619573,0.00005380019,0.0001629767,0.00002576023,0.001002396],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08078106,"threshold_uncertainty_score":0.6637754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03721356233981105,"score_gpt":0.3517585838036483,"score_spread":0.3145450214638373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}