{"id":"W3162250795","doi":"10.3390/ijms22105290","title":"Calvaria Bone Transcriptome in Mouse Models of Osteogenesis Imperfecta","year":2021,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Shriners Hospitals for Children - Canada","funders":"Québec Consortium for Drug Discovery; Réseau de Recherche en Santé Buccodentaire et Osseuse","keywords":"Osteogenesis imperfecta; Calvaria; Transcriptome; Downregulation and upregulation; Wnt signaling pathway; Biology; Gene; Sclerostin; Endocrinology; Internal medicine; Genetics; Gene expression; Medicine; Anatomy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000509051,0.00007268223,0.0001376375,0.000203694,0.00001833589,0.00002937733,0.0004771063,0.00005004295,0.00004311888],"category_scores_gemma":[0.0002256771,0.00006839778,0.000129238,0.0002096699,0.0001401343,0.00001751096,0.00009012379,0.00007875049,6.648361e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000208975,"about_ca_system_score_gemma":0.0003730239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004960234,"about_ca_topic_score_gemma":0.00007200654,"domain_scores_codex":[0.9986798,0.0001118732,0.000310813,0.000172236,0.0005914834,0.000133774],"domain_scores_gemma":[0.9990343,0.0000200592,0.0001235366,0.000100691,0.0006741277,0.00004724901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006906299,0.00009857212,0.00133955,0.000004112577,0.00006091149,0.0001447481,0.0001144965,0.003541586,0.9917402,0.0005300925,0.0000197124,0.002336921],"study_design_scores_gemma":[0.000653689,0.0002214795,0.0007247144,0.00002411761,0.000005653039,0.0001795196,0.0003153701,0.0005331654,0.9961132,0.0008907784,0.0002579287,0.00008033649],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880829,0.004086441,0.006472091,0.0006160588,0.0001438686,0.00004041924,0.00001305905,8.344439e-7,0.0005443002],"genre_scores_gemma":[0.9982604,0.0003921521,0.001135063,0.00009310132,0.00003490539,0.000001706627,0.000004878966,0.000006202389,0.00007157058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01017749,"threshold_uncertainty_score":0.278918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02186429951632889,"score_gpt":0.3176114259609102,"score_spread":0.2957471264445813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}