{"id":"W3162252881","doi":"10.1101/2021.05.20.445072","title":"Rational Drug Design of Targeted and Enzyme Cleavable Vitamin E Analogs as Neoadjuvant to Chemotherapy: <i>In Vitro</i> and <i>In Vivo</i> Evaluation on Reduction of Cardiotoxicity of Doxorubicin","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Cardiotoxicity; Doxorubicin; In vivo; Pharmacology; Cancer cell; Chemotherapy; Medicine; Cancer; Drug; Cancer research; Breast cancer; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001470482,0.0002164491,0.0002572259,0.0001872382,0.00008494063,0.0002491933,0.0001966432,0.0002428264,0.0009639771],"category_scores_gemma":[0.0001220541,0.0001286409,0.0002526546,0.0001488642,0.0001292574,0.000222818,0.0001244722,0.0003770591,0.0002055871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001973334,"about_ca_system_score_gemma":0.0001696333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002506225,"about_ca_topic_score_gemma":0.0004842893,"domain_scores_codex":[0.9999472,0.00001135808,0.000005789466,0.00001322432,0.00001305891,0.000009297053],"domain_scores_gemma":[0.9999641,0.000006303624,0.00001311657,0.00000329886,0.00000666868,0.000006445262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006865113,0.0002473816,0.0002618049,0.0004019753,0.00002624695,0.0001569929,0.00002655039,0.003276604,0.979228,0.001117371,0.0002903158,0.01428036],"study_design_scores_gemma":[0.0002094839,0.003552785,0.0005337583,0.0000319527,0.00004830819,0.000252656,0.00002489056,0.003861493,0.9790322,0.0002253947,0.01220801,0.00001904562],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9563347,0.01768603,0.01824464,0.0003660342,0.000085504,0.0003169348,0.0007433454,0.0001076483,0.006115301],"genre_scores_gemma":[0.9771234,0.007315147,0.01286608,0.0001069834,0.00001000319,0.0001203824,0.0003684452,0.00001429895,0.002075419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009639771,"threshold_uncertainty_score":0.00322485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00939713946654003,"score_gpt":0.2273303284791687,"score_spread":0.2179331890126286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}