{"id":"W3162259891","doi":"10.1038/s41588-021-00857-4","title":"Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology","year":2021,"lang":"en","type":"review","venue":"Nature Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1593,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; McGill University; Dalhousie University; Montreal Neurological Institute and Hospital; University of Toronto; Centre for Addiction and Mental Health; McGill University Health Centre","funders":"National Institute of Mental Health; Medical Research Council; Institute of Psychiatry, Psychology and Neuroscience, King’s College London; School of Medicine, Emory University; National Institutes of Health; Université de Paris; Assistance publique-Hôpitaux de Paris; University of Cape Town; Centre d'Imagerie BioMédicale; Universitat de Barcelona; Háskóli Íslands; Universitetet i Oslo; Umeå Universitet; University of California, Irvine; Universidad Autónoma de Madrid; McDonnell Center for Systems Neuroscience; University of Melbourne; University of Toronto; University of Glasgow; University of New South Wales; South African Medical Research Council; Universidad de Granada; Karolinska Institutet; School of Medicine, University of California, Irvine; Lundbeckfonden; Institut National de la Santé et de la Recherche Médicale; Emory University; Westfälische Wilhelms-Universität Münster; University of Oxford; Neuroscience Research Australia; Vanderbilt University; King's College London; Diakonhjemmet; Centro de Biología Molecular Severo Ochoa; Vanderbilt University Medical Center; Pfizer; National Institute for Health and Care Research; Agence Nationale de la Recherche; University of Southern California; World Health Organization; U.S. Department of Health and Human Services","keywords":"Biology; Genome-wide association study; Computational biology; Bipolar disorder; Genetics; Genetic association; Genome; Association (psychology); Evolutionary biology; Single-nucleotide polymorphism; Gene; Genotype; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001784831,0.001304807,0.002232302,0.002919754,0.0002336223,0.0009896174,0.001181815,0.001475878,0.002865192],"category_scores_gemma":[0.001877106,0.0003724477,0.0006223791,0.002995526,0.0006247158,0.0009938201,0.0007895217,0.002029811,0.002263399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009960505,"about_ca_system_score_gemma":0.001678309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00193546,"about_ca_topic_score_gemma":0.003457177,"domain_scores_codex":[0.9996206,0.00008664749,0.00005617339,0.00008945375,0.0001164279,0.00003078227],"domain_scores_gemma":[0.9985613,0.0008232832,0.0001254112,0.00004056617,0.0003197267,0.0001296599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0001035836,0.00002834526,0.0004581205,0.008993009,0.0002682472,0.0001723708,0.00002513005,0.0001878738,0.0005212908,0.001994602,0.03715173,0.9500957],"study_design_scores_gemma":[0.00004413889,0.0001230177,0.003495879,0.005903939,0.0004663277,0.001533002,0.00005150192,0.00007650476,0.0002879475,0.002744545,0.9852408,0.00003236781],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005834682,0.9985532,0.0001265332,0.0004487979,0.0001679988,0.00000348941,0.00003462511,0.00000837386,0.0005986469],"genre_scores_gemma":[0.0004127045,0.9984531,0.0001660305,0.0003656347,0.0001825878,0.000005594202,0.0000716821,0.000002362859,0.0003402074],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002919754,"threshold_uncertainty_score":0.009585023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03286501014639599,"score_gpt":0.3429791408239471,"score_spread":0.3101141306775512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}