{"id":"W3162278982","doi":"10.1101/2020.06.26.174342","title":"When killers become thieves: trogocytosed PD-1 inhibits NK cells in cancer","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute; McGill University; Ottawa Hospital; University of Ottawa","funders":"","keywords":"Cytotoxic T cell; Immune system; Biology; Natural killer T cell; Cell biology; CD8; Immune checkpoint; Leukemia; Immunology; Cancer research; Immunotherapy; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002394781,0.0001973519,0.0002737572,0.0001437169,0.0001553274,0.0002704219,0.0001803135,0.0003835515,0.004729772],"category_scores_gemma":[0.0001653178,0.0000737409,0.000119584,0.0000756041,0.0001964177,0.0002200891,0.0001456185,0.0005997676,0.0009123203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002348356,"about_ca_system_score_gemma":0.0001547883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001142465,"about_ca_topic_score_gemma":0.0002564337,"domain_scores_codex":[0.999887,0.00002402041,0.00001498195,0.00001871686,0.00003490382,0.00002027313],"domain_scores_gemma":[0.9999321,0.00001449933,0.00001976191,0.000005975876,0.00001076377,0.00001699118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00149534,0.0001214434,0.0009817993,0.0008581429,0.00004741924,0.0005837411,0.00008815929,0.0002734505,0.9268121,0.003052138,0.0237848,0.04190159],"study_design_scores_gemma":[0.0002942337,0.001124171,0.005239334,0.0000646554,0.00005379536,0.00197335,0.0001048422,0.001158558,0.8797926,0.0008332385,0.1093458,0.00001543874],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8439393,0.07363972,0.01448218,0.02230234,0.01122876,0.0003258428,0.001769448,0.00163418,0.03067824],"genre_scores_gemma":[0.9380518,0.009472175,0.003226388,0.00253122,0.0009500948,0.0001225687,0.0006180899,0.00006500786,0.0449626],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004729772,"threshold_uncertainty_score":0.01582271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01905661341086403,"score_gpt":0.2276599224748571,"score_spread":0.208603309063993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}